Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

96 questions · 135 findings · 7 reviews

No studies found 35 · 25.9%GRADE not reported 30 · 22.2%Very low 34 · 25.2%Low 6 · 4.4%Moderate 13 · 9.6%High 17 · 12.6%

Silver diamine fluoride (SDF) vs Control (placebo/no treatment or other topical fluoride agents)

Prevention of new caries (caries development/increment) · Preschool children (primary dentition) at risk of new caries

Limited evidence from two trials suggests SDF may help prevent new caries, but preventive efficacy was not meta-analyzed and remains uncertain (ungraded).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Sealants or resin infiltration

Secondary prevention of caries · Children and adults (with or without carious lesions)

Silver diamine fluoride (SDF) showed no clear difference in secondary prevention of caries compared with sealants or resin infiltration; GRADE not reported.

1 finding from 1 review

Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material

Secondary prevention of caries · Children and adults (with or without carious lesions)

The review found no eligible studies for this question.

1 finding from 1 review

Silver diamine fluoride (SDF) vs Sealants or resin infiltration

Primary caries prevention · Children and adults (with or without carious lesions)

The review found no eligible studies for this question.

3 findings from 1 review

Silver diamine fluoride (SDF) vs placebo or no treatment

Secondary prevention of caries · Children and adults (with or without carious lesions)

The review found no eligible studies for this question.

3 findings from 1 review

Silver diamine fluoride (SDF) vs Fluoride varnish

Primary caries prevention · Children and adults (with or without carious lesions)

It is very uncertain whether silver diamine fluoride (SDF) changes primary caries prevention compared with fluoride varnish (very low certainty).

3 findings from 1 review

Silver diamine fluoride (SDF) vs placebo or no treatment

Primary caries prevention · Children and adults (with or without carious lesions)

It is very uncertain whether silver diamine fluoride (SDF) changes primary caries prevention compared with placebo or no treatment (very low certainty).

3 findings from 1 review

Silver diamine fluoride (SDF) vs Fluoride varnish

Secondary prevention of caries · Children and adults (with or without carious lesions)

The review found no eligible studies for this question.

3 findings from 1 review

Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material

Primary caries prevention · Children and adults (with or without carious lesions)

The review found no eligible studies for this question.

1 finding from 1 review

Silver diamine fluoride (SDF) vs Chlorhexidine varnish

Primary caries prevention · Children and adults (with or without carious lesions)

It is very uncertain whether silver diamine fluoride (SDF) changes primary caries prevention compared with chlorhexidine varnish (very low certainty).

1 finding from 1 review

38% silver diamine fluoride vs Glass ionomer cement (GIC) plus fluoride varnish

Caries prevention (preventive fraction, SDF vs GIC+5% fluoride varnish) · intellectually disabled individuals with caries in permanent posterior teeth

SDF had a 45% preventative fraction versus glass ionomer cement plus fluoride varnish; no pooled estimate or GRADE rating was reported.

1 finding from 1 review