Findings

What do systematic reviews say?

108 questions · 125 findings · 5 reviews

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No studies found 36 · 28.8%GRADE not reported 44 · 35.2%Very low 34 · 27.2%Low 6 · 4.8%Moderate 5 · 4%High 0 · 0%

Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material

Aesthetics · Children and adults (with or without carious lesions)

1 finding from 1 review

Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults 2024 · Cochrane All outcomes
24 months · Children
1 study reported that 45% of parents were satisfied with appearance of their child's teeth; data not reported by study group. 1 study reported that 1 of 34 caregivers in SDF group were "annoyed with teeth appearance",…
2 studies · 248 participants
Very low

38% SDF + potassium iodide solution (applied annually) vs CPP-ACP

Remineralization/arrest of early enamel carious lesions · Patients with early enamel carious lesions on permanent molars

For early enamel lesions, annual SDF+KI was significantly less effective than twice-daily CPP-ACP (54.8% vs 100% arrested; p<0.001; ungraded).

1 finding from 1 review

A systematic review on the effect of silver diamine fluoride for management of dental caries in permanent teeth. 2023 All outcomes
24 months · Outpatient clinic · Hamdi 2022
Proportion of lesions arrested (%) 54.8
1 study · 45 participants
GRADE not reported

Prior application of silver diamine fluoride (SDF), with or without a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Dental adhesives/resin composite bonded to dentin (in vitro), sound or caries-affected

Prior SDF application significantly reduces the immediate bond strength of adhesives to dentin overall (MD 7.12 MPa favoring untreated dentin, 95% CI 1.38 to 12.85; ungraded), with very high heterogeneity (I2=98%).

1 finding from 1 review

Bonding of Glass-Ionomer Cement and Adhesives to Silver Diamine Fluoride-treated Dentin: An Updated Systematic Review… 2022 All outcomes
Immediate bond strength · In vitro (laboratory bond-strength testing) · Overall (all dentin conditions and rinsing protocols)
MD 7.12 [1.38, 12.85]
11 studies · 526 participants
GRADE not reported

38% SDF + potassium iodide solution (applied annually) vs Tricalcium silicate (TCS) paste (applied twice daily)

Remineralization/arrest of early enamel carious lesions · Patients with early enamel carious lesions on permanent molars

For early enamel lesions, annual SDF+KI was significantly LESS effective than twice-daily tricalcium silicate paste (54.8% vs 100% arrested; p<0.001; ungraded).

1 finding from 1 review

A systematic review on the effect of silver diamine fluoride for management of dental caries in permanent teeth. 2023 All outcomes
24 months · Outpatient clinic · Hamdi 2022 (early enamel lesions, Egypt)
Proportion of lesions arrested (%) 54.8
1 study · 45 participants
GRADE not reported

Silver diamine fluoride (SDF) plus fluoride varnish vs Sealants plus fluoride varnish (with or without restorations)

Aesthetics · Children and adults (with or without carious lesions)

The review found no eligible studies for this question.

1 finding from 1 review

Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults 2024 · Cochrane All outcomes
No studies reported data for this outcome in this comparison
0 studies
No studies found

Silver diamine fluoride (SDF) plus fluoride varnish vs Sealants plus fluoride varnish (with or without restorations)

Adverse effects · Children and adults (with or without carious lesions)

1 finding from 1 review

Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults 2024 · Cochrane All outcomes
Study period (24 months) · Children
Ruff 2022 reported that there were no adverse events during the study period; adverse events were not defined by the study authors. Assumed data available for 1398 participants.
1 study · 1398 participants
Very low

SDF (given at a particular frequency, concentration, or duration) vs SDF (given at a different frequency, concentration, or duration)

Aesthetics · Children and adults (with or without carious lesions)

1 finding from 1 review

Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults 2024 · Cochrane All outcomes
24 months · Children
1 study (119 children) reported that 45% parents were satisfied with child's dental appearance (data not reported by study group)
1 study · 119 participants
Very low

SDF (given at a particular frequency, concentration, or duration) vs SDF (given at a different frequency, concentration, or duration)

Adverse effects · Children and adults (with or without carious lesions)

1 finding from 1 review

Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults 2024 · Cochrane All outcomes
24 to 30 months · Children
1 study (203 children) reported that black or brown staining on treated lesions was commonly found in both groups, with little or no difference according to whether SDF treatment was given in 3 applications at…
3 studies · 1121 participants
Very low