Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Common Mental Disorders

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 50%High 3 · 50%

Sildenafil vs placebo

Global Efficacy Questionnaire (questions 1 & 2) (Questions assessing improvement attributed to medication compared to having no treatment at all) · people with antidepressant‐induced sexual dysfunction

Sildenafil probably leads to higher global Efficacy Questionnaire (questions 1 & 2) (Questions assessing… compared with placebo (moderate certainty).

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
RR 2.5 [1.67, 3.73]
1 study · 284 participants
Moderate

Sildenafil vs placebo

Endpoint International Index of Erectile Function (IIEF) total scores (The IIEF is a self‐report measure with 15 questions examining erectile function, orgasmic function, sexual desire, and intercourse satisfaction. Maximum possible score 75) · people with antidepressant‐induced sexual dysfunction

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 112 participants
High

Sildenafil vs placebo

Endpoint International Index of Erectile Function (IIEF) scores ‐ question 3: ability to achieve erection (Maximum score 5) · people with antidepressant‐induced sexual dysfunction

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 231 participants
High

Sildenafil vs placebo

Endpoint International Index of Erectile Function (IIEF) scores ‐ intercourse satisfaction (questions 6, 7, 8) (Maximum score 15) · people with antidepressant‐induced sexual dysfunction

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 89 participants
Moderate

Sildenafil vs placebo

Effect on later sexual function · people with antidepressant‐induced sexual dysfunction

Sildenafil probably leads to lower clinical Global Impression ‐Sexual Function not "much/very much… compared with placebo (moderate certainty).

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
RR 0.44 [0.33, 0.58]
2 studies · 187 participants
Moderate

Sildenafil vs placebo

Dropout · people with antidepressant‐induced sexual dysfunction

Sildenafil showed no clear difference in dropouts (People leaving the trial early) compared with placebo (high certainty).

1 finding from 1 review

Strategies for managing sexual dysfunction induced by antidepressant medication 2013 · Cochrane Headline outcomes only
RR 0.68 [0.41, 1.14]
4 studies · 353 participants
High