What do systematic reviews say?

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

• Short‐course versus prolonged‐course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 431 participants
  Low

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Should short‐course antibiotic therapy showed no clear difference in mortality compared with prolonged‐course antibiotic therapy be used (moderate certainty).

• Short‐course versus prolonged‐course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults 2015 · Cochrane Headline outcomes only
  OR 1.18 [0.77, 1.8]
  3 studies · 598 participants
  Moderate

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Should short‐course antibiotic therapy showed no clear difference in mortality NF‐GNB compared with prolonged‐course antibiotic therapy be used (low certainty).

• Short‐course versus prolonged‐course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults 2015 · Cochrane Headline outcomes only
  OR 0.95 [0.39, 2.27]
  2 studies · 179 participants
  Low

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Should short‐course antibiotic therapy showed no clear difference in mortality MRSA compared with prolonged‐course antibiotic therapy be used (moderate certainty).

• Short‐course versus prolonged‐course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults 2015 · Cochrane Headline outcomes only
  OR 1.28 [0.32, 5.09]
  1 study · 42 participants
  Moderate

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Should short‐course antibiotic therapy showed no clear difference in recurrence of pneumonia Clinical and/or microbiological criteria compared with prolonged‐course antibiotic therapy be used (low certainty).

• Short‐course versus prolonged‐course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults 2015 · Cochrane Headline outcomes only
  OR 1.41 [0.94, 2.12]
  19 studies · 733 participants
  Low

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Should short‐course antibiotic therapy probably leads to higher recurrence of pneumonia NF‐GNB Clinical and/or microbiological… compared with prolonged‐course antibiotic therapy be used (moderate certainty).

• Short‐course versus prolonged‐course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults 2015 · Cochrane Headline outcomes only
  OR 2.18 [1.14, 4.16]
  2 studies · 176 participants
  Moderate

Antibiotics (short duration) vs prolonged‐course antibiotic therapy be used

Should short‐course antibiotic therapy showed no clear difference in recurrence of pneumonia MRSA Clinical and/or microbiological criteria compared with prolonged‐course antibiotic therapy be used (moderate certainty).

• Short‐course versus prolonged‐course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults 2015 · Cochrane Headline outcomes only
  OR 1.56 [0.12, 19.61]
  2 studies · 49 participants
  Moderate