What do systematic reviews say?

Summary of findings: Sevelamer vs calcium carbonate

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low

Summary of findings: Sevelamer vs calcium carbonate

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low

Summary of findings: Sevelamer vs calcium

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 517 participants
  Low

Summary of findings: Sevelamer vs calcium carbonate

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low

Summary of findings: Sevelamer vs calcium carbonate

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low

Summary of findings: Sevelamer vs calcium carbonate

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low

Summary of findings: Sevelamer vs calcium carbonate

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low

Summary of findings: Sevelamer vs calcium carbonate

• Interventions for bone disease in children with chronic kidney disease 2010 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low

Summary of findings: Sevelamer vs calcium

Summary of findings: Sevelamer may leads to lower death (all causes) compared with calcium (low certainty).

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  RR 0.53 [0.3, 0.91]
  16 studies · 3688 participants
  Low

Summary of findings: Sevelamer vs calcium

It is very uncertain whether summary of findings: Sevelamer changes cardiovascular death compared with calcium (very low certainty).

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  RR 0.45 [0.11, 1.77]
  6 studies · 2829 participants
  Very low

Summary of findings: Sevelamer vs calcium

It is very uncertain whether summary of findings: Sevelamer changes hypercalcaemia compared with calcium (very low certainty).

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  RR 0.3 [0.2, 0.43]
  19 studies · 4084 participants
  Very low

Summary of findings: Sevelamer vs calcium

Summary of findings: Sevelamer showed no clear difference in nausea compared with calcium (low certainty).

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  RR 0.98 [0.56, 1.71]
  4 studies · 365 participants
  Low

Summary of findings: Sevelamer vs calcium

Summary of findings: Sevelamer showed no clear difference in vomiting compared with calcium (low certainty).

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  RR 0.95 [0.54, 1.69]
  2 studies · 263 participants
  Low

Summary of findings: Sevelamer vs calcium

Summary of findings: Sevelamer showed no clear difference in constipation compared with calcium (low certainty).

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  RR 1.35 [0.71, 2.57]
  6 studies · 2652 participants
  Low

Summary of findings: Sevelamer vs calcium

• Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
  no estimate extracted
  23 studies · 4360 participants
  Very low