Self-assembling peptide P11-4 vs Placebo or no active treatment
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Self-assembling peptide P11-4 significantly improved remineralization versus control (SMD -0.56, 95% CI -0.96 to -0.15); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
- Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. 2023 All outcomesRCTs (clinical and in vitro); predominantly children and adolescents; orthodontic and non-orthodontic white spot lesions, early caries lesions, and artificial lesionsSMD -0.56 [-0.96, -0.15]4 studiesGRADE not reported