Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

91 questions · 93 findings · 4 reviews · Vascular

No studies found 36 · 38.7%GRADE not reported 5 · 5.4%Very low 10 · 10.8%Low 18 · 19.4%Moderate 24 · 25.8%High 0 · 0%

Foam sclerotherapy vs foam sclerotherapy

Cosmetic appearance · participants with varicose veinsa

It is very uncertain whether foam sclerotherapy changes cosmetic appearance (self‐described cosmetic improvement) compared with foam sclerotherapy (very low certainty).

1 finding from 1 review

Foam sclerotherapy vs foam sclerotherapy

Number of thromboembolic complications · participants with varicose veinsa

It is very uncertain whether foam sclerotherapy changes complications ‐ thromboembolic compared with foam sclerotherapy (very low certainty).

1 finding from 1 review

Sclerotherapy vs placebo

Adverse events ‐ hyperpigmentation ( · people with telangiectasias and reticular veins

Sclerotherapy probably leads to higher adverse events ‐ hyperpigmentation ( compared with placebo (moderate certainty).

1 finding from 1 review