What do systematic reviews say?

5 questions · 15 findings · 2 reviews · Oral Health

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No studies found 0 · 0%GRADE not reported 14 · 93.3%Very low 0 · 0%Low 0 · 0%Moderate 1 · 6.7%High 0 · 0%

Resin infiltration vs Baseline before resin infiltration

Lightness change · Patients with post-orthodontic white spot lesions and permanent dentition

Knosel (2019) reported a statistically significant lightness-change effect.

3 findings from 1 review

Changes in the Color and Brightness of White Spots Associated with Orthodontic Treatment 6 Months after the… 2022 All outcomes
6 months · Permanent teeth
Cohen's d 0.71 [0.32, 1.09]
1 study
GRADE not reported
Changes in the Color and Brightness of White Spots Associated with Orthodontic Treatment 6 Months after the… 2022 All outcomes
6 months · Permanent teeth
Cohen's d -1.76 [-2.22, -1.30]
1 study
GRADE not reported
Changes in the Color and Brightness of White Spots Associated with Orthodontic Treatment 6 Months after the… 2022 All outcomes
6 months · Permanent teeth
Cohen's d 0.40 [0.11, 0.65]
1 study
GRADE not reported

Resin infiltration vs Baseline before resin infiltration

Color change · Patients with post-orthodontic white spot lesions and permanent dentition

Eckstein (2015) reported a statistically significant color-change effect.

4 findings from 1 review

Changes in the Color and Brightness of White Spots Associated with Orthodontic Treatment 6 Months after the… 2022 All outcomes
6 months · Permanent teeth
Cohen's d 0.40 [0.11, 0.65]
1 study
GRADE not reported
Changes in the Color and Brightness of White Spots Associated with Orthodontic Treatment 6 Months after the… 2022 All outcomes
6 months · Permanent teeth
Cohen's d 0.82 [0.43, 1.20]
1 study
GRADE not reported
Changes in the Color and Brightness of White Spots Associated with Orthodontic Treatment 6 Months after the… 2022 All outcomes
6 months · Permanent teeth
Cohen's d 6.80 [5.70, 7.82]
1 study
GRADE not reported

Show 1 more finding

Changes in the Color and Brightness of White Spots Associated with Orthodontic Treatment 6 Months after the… 2022 All outcomes
6 months · Permanent teeth
Cohen's d 2.37 [1.91, 2.82]
1 study
GRADE not reported

Resin infiltration vs Non-invasive treatment

Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition)

Resin infiltration probably reduces the odds of proximal lesion progression compared with non-invasive treatment (OR 0.21, 95% CI 0.15 to 0.29; moderate certainty).

6 findings from 1 review

Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. 2021 All outcomes
Longest available follow-up
OR 0.21 [0.15, 0.30]
11 studies · 549 participants
Moderate
Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. 2021 All outcomes
Longest available follow-up · Caries risk: low
OR 0.24 [0.08, 0.72]
2 studies
GRADE not reported
Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. 2021 All outcomes
Longest available follow-up · Caries risk: moderate to high
OR 0.20 [0.10, 0.39]
3 studies
GRADE not reported

Show 3 more findings

Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. 2021 All outcomes
Longest available follow-up · Caries risk: moderate
OR 0.32 [0.01, 8.27]
1 study
GRADE not reported
Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. 2021 All outcomes
Longest available follow-up · Caries risk: high
OR 0.14 [0.05, 0.37]
2 studies
GRADE not reported
Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. 2021 All outcomes
Longest available follow-up · Caries risk: low to moderate
OR 0.38 [0.18, 0.81]
1 study
GRADE not reported

Resin infiltration vs Pre-treatment baseline before infiltration (T0); pooled as a within-arm before/after change

Lightness/brightness change of white spot lesion (luminosity L*, T0 to T1) · Patients with post-orthodontic white spot lesions and permanent dentition

ICON resin infiltration showed no statistically significant change in lightness/brightness of post-orthodontic white spot lesions at 6 months (pooled Cohen's d/SMD -0.001, 95% CI -0.23 to 0.23; 3 studies, 330 teeth; I2=97%); not GRADE-rated.

1 finding from 1 review

Changes in the Color and Brightness of White Spots Associated with Orthodontic Treatment 6 Months after the… 2022 All outcomes
6 months · Post-orthodontic patients after fixed appliance removal; permanent dentition; in vivo clinical trials
SMD -0.001 [-0.23, 0.23]
3 studies · 330 participants
GRADE not reported

Resin infiltration vs Pre-treatment baseline before infiltration (T0); pooled as a within-arm before/after change

Color change of white spot lesion (color difference, T0 to T1) · Patients with post-orthodontic white spot lesions and permanent dentition

ICON resin infiltration significantly improved the color of post-orthodontic white spot lesions at 6 months (pooled Cohen's d/SMD 1.36, 95% CI 1.14 to 1.59; 4 studies, 458 teeth), although heterogeneity was very high (I2=98%) with a heavy outlier (Kannan); not GRADE-rated.

1 finding from 1 review

Changes in the Color and Brightness of White Spots Associated with Orthodontic Treatment 6 Months after the… 2022 All outcomes
6 months · Post-orthodontic patients after fixed appliance removal; permanent dentition; in vivo clinical trials
SMD 1.36 [1.14, 1.59]
4 studies · 458 participants
GRADE not reported