Optical/esthetic improvement (visual-tactile assessment) · Patients with post-orthodontic white spot lesions (WSL)
Resin infiltration produced significantly greater optical improvement of white spot lesions than untreated (naturally remineralizing) controls (SMD 1.24, 95% CI 0.59 to 1.88; moderate certainty).
4 findings from 1 review
SMD 1.24 [0.59, 1.88]
3 studies · 949 participants
Moderate
SMD 2.34 [1.68, 3.01]
1 study · 66 participants
GRADE not reported
SMD 0.63 [0.26, 1.01]
1 study · 115 participants
GRADE not reported
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Optical/esthetic improvement (DIAGNOdent reading) · Patients (mainly children) with white spot lesions (WSL)
Resin infiltration produced significantly greater optical improvement than fluoride varnish (MD 4.76, 95% CI 0.74 to 8.78; moderate certainty).
3 findings from 1 review
MD 4.76 [0.74, 8.78]
3 studies · 212 participants
Moderate
MD 3.65 [0.82, 6.48]
2 studies · 172 participants
GRADE not reported
MD 13.15 [3.98, 22.32]
1 study · 40 participants
GRADE not reported
Masking effect / color improvement · Patients with white spot lesions or developmental enamel defects
Two studies compared resin infiltration with microabrasion, but no pooled or comparative effect estimate was reported (ungraded).
1 finding from 1 review
no estimate extracted
2 studies
GRADE not reported
Lightness change · Patients with post-orthodontic white spot lesions and permanent dentition
Knosel (2019) reported a statistically significant lightness-change effect.
3 findings from 1 review
Cohen's d 0.71 [0.32, 1.09]
1 study
GRADE not reported
Cohen's d -1.76 [-2.22, -1.30]
1 study
GRADE not reported
Cohen's d 0.40 [0.11, 0.65]
1 study
GRADE not reported
Color change · Patients with post-orthodontic white spot lesions and permanent dentition
Eckstein (2015) reported a statistically significant color-change effect.
4 findings from 1 review
Cohen's d 0.40 [0.11, 0.65]
1 study
GRADE not reported
Cohen's d 0.82 [0.43, 1.20]
1 study
GRADE not reported
Cohen's d 6.80 [5.70, 7.82]
1 study
GRADE not reported
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Dentist satisfaction (masking effect) · Patients with dental fluorosis
Resin infiltration alone produced greater dentist-rated masking than in-office bleaching alone in one study (MD 3.97, 95% CI 3.33 to 4.61; ungraded).
1 finding from 1 review
MD 3.97 [3.33, 4.61]
1 study
GRADE not reported
Patient/dentist satisfaction · Patients with dental fluorosis
Patient/dentist satisfaction did not differ between bleaching-then-infiltration and infiltration alone (SMD -1.53, 95% CI -4.75 to 1.70; ungraded).
1 finding from 1 review
SMD -1.53 [-4.75, 1.70]
2 studies
GRADE not reported
Masking effect (esthetic improvement) · Patients with dental fluorosis
Bleaching before resin infiltration did not improve masking of fluorosis compared with infiltration alone (MD -0.30, 95% CI -0.98 to 0.39; moderate certainty).
1 finding from 1 review
MD -0.30 [-0.98, 0.39]
2 studies
Moderate
Lightness/brightness change of white spot lesion (luminosity L*, T0 to T1) · Patients with post-orthodontic white spot lesions and permanent dentition
ICON resin infiltration showed no statistically significant change in lightness/brightness of post-orthodontic white spot lesions at 6 months (pooled Cohen's d/SMD -0.001, 95% CI -0.23 to 0.23; 3 studies, 330 teeth; I2=97%); not GRADE-rated.
1 finding from 1 review
Color change of white spot lesion (color difference, T0 to T1) · Patients with post-orthodontic white spot lesions and permanent dentition
ICON resin infiltration significantly improved the color of post-orthodontic white spot lesions at 6 months (pooled Cohen's d/SMD 1.36, 95% CI 1.14 to 1.59; 4 studies, 458 teeth), although heterogeneity was very high (I2=98%) with a heavy outlier (Kannan); not GRADE-rated.
1 finding from 1 review