Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Hypertension

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 5 · 71.4%Moderate 1 · 14.3%High 0 · 0%

All‐cause mortality · people with primary hypertension

Renin inhibitors showed no clear difference in all‐cause mortality compared with ACE inhibitors (low certainty).

1 finding from 1 review

Renin inhibitors versus angiotensin converting enzyme (ACE) inhibitors for primary hypertension 2020 · Cochrane Headline outcomes only
RR 1.05 [0.93, 1.18]
5 studies · 5962 participants
Low

Fatal or nonfatal myocardial infarction · people with primary hypertension

It is very uncertain whether renin inhibitors changes fatal or non‐fatal myocardial infarction compared with ACE inhibitors (very low certainty).

1 finding from 1 review

Renin inhibitors versus angiotensin converting enzyme (ACE) inhibitors for primary hypertension 2020 · Cochrane Headline outcomes only
RR 0.86 [0.22, 3.39]
2 studies · 957 participants
Very low

Adverse events · people with primary hypertension

Renin inhibitors showed no clear difference in adverse events compared with ACE inhibitors (moderate certainty).

1 finding from 1 review

Renin inhibitors versus angiotensin converting enzyme (ACE) inhibitors for primary hypertension 2020 · Cochrane Headline outcomes only
RR 0.98 [0.93, 1.03]
10 studies · 6007 participants
Moderate

Fatal or non‐fatal serious adverse events · people with primary hypertension

Renin inhibitors showed no clear difference in fatal or non‐fatal serious adverse events compared with ACE inhibitors (low certainty).

1 finding from 1 review

Renin inhibitors versus angiotensin converting enzyme (ACE) inhibitors for primary hypertension 2020 · Cochrane Headline outcomes only
RR 1.21 [0.89, 1.64]
10 studies · 6007 participants
Low

WDAEs · people with primary hypertension

Renin inhibitors showed no clear difference in withdrawal due to adverse effects (WDAE) compared with ACE inhibitors (low certainty).

1 finding from 1 review

Renin inhibitors versus angiotensin converting enzyme (ACE) inhibitors for primary hypertension 2020 · Cochrane Headline outcomes only
RR 0.85 [0.68, 1.06]
10 studies · 6008 participants
Low

Systolic blood pressure · people with primary hypertension

1 finding from 1 review

Renin inhibitors versus angiotensin converting enzyme (ACE) inhibitors for primary hypertension 2020 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 5001 participants
Low

Diastolic blood pressure · people with primary hypertension

1 finding from 1 review

Renin inhibitors versus angiotensin converting enzyme (ACE) inhibitors for primary hypertension 2020 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 5001 participants
Low