Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 1 · 50%High 0 · 0%

Adverse events · people with primary hypertension

Renin inhibitors showed no clear difference in adverse events compared with ACE inhibitors (moderate certainty).

1 finding from 1 review

Renin inhibitors versus angiotensin converting enzyme (ACE) inhibitors for primary hypertension 2020 · Cochrane Headline outcomes only
RR 0.98 [0.93, 1.03]
10 studies · 6007 participants
Moderate

Fatal or non‐fatal serious adverse events · people with primary hypertension

Renin inhibitors showed no clear difference in fatal or non‐fatal serious adverse events compared with ACE inhibitors (low certainty).

1 finding from 1 review

Renin inhibitors versus angiotensin converting enzyme (ACE) inhibitors for primary hypertension 2020 · Cochrane Headline outcomes only
RR 1.21 [0.89, 1.64]
10 studies · 6007 participants
Low