Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 0 · 0%Moderate 2 · 50%High 1 · 25%

Regular formoterol and ICS vs same‐dose ICS

Non‐fatal serious adverse events · adults, chronic asthma: all‐cause mortality

Regular formoterol and ICS showed no clear difference in all‐cause non‐fatal serious adverse events compared with same‐dose ICS (high certainty).

1 finding from 1 review

Inhaled steroids with and without regular formoterol for asthma: serious adverse events 2019 · Cochrane Headline outcomes only
OR 1 [0.87, 1.16]
32 studies · 35751 participants
High

Regular formoterol and ICS vs same‐dose ICS

Non‐fatal serious adverse events · children and adolescents with chronic asthma

Regular formoterol and ICS showed no clear difference in all‐cause non‐fatal serious adverse events compared with same‐dose ICS (moderate certainty).

1 finding from 1 review

Inhaled steroids with and without regular formoterol for asthma: serious adverse events 2019 · Cochrane Headline outcomes only
OR 1.33 [0.71, 2.49]
10 studies · 4035 participants
Moderate

Regular formoterol and ICS vs same‐dose ICS

Asthma‐related non‐fatal serious adverse events · adults, chronic asthma: all‐cause mortality

Regular formoterol and ICS showed no clear difference in asthma‐related non‐fatal serious adverse events compared with same‐dose ICS (moderate certainty).

1 finding from 1 review

Inhaled steroids with and without regular formoterol for asthma: serious adverse events 2019 · Cochrane Headline outcomes only
OR 0.86 [0.64, 1.14]
30 studies · 35158 participants
Moderate

Regular formoterol and ICS vs same‐dose ICS

Asthma‐related non‐fatal serious adverse events · children and adolescents with chronic asthma

It is very uncertain whether regular formoterol and ICS changes asthma‐related non‐fatal serious adverse events compared with same‐dose ICS (very low certainty).

1 finding from 1 review

Inhaled steroids with and without regular formoterol for asthma: serious adverse events 2019 · Cochrane Headline outcomes only
OR 1.18 [0.4, 3.51]
10 studies · 4035 participants
Very low