Reduction and pharmacotherapy may leads to higher main analysis (all pharmacotherapy): smoking cessation (≥ 6 month compared with reduction alone (low certainty).
Reduction and pharmacotherapy showed no clear difference in subgroup: combination NRT; smoking cessation (≥ 6 month compared with reduction alone (low certainty).
It is very uncertain whether reduction and pharmacotherapy changes subgroup: nicotine patch; smoking cessation (≥ 6 month compared with reduction alone (very low certainty).
Reduction and pharmacotherapy probably leads to higher subgroup: fast‐acting NRT only; smoking cessation (≥ 6 month compared with reduction alone (moderate certainty).
Reduction and pharmacotherapy probably leads to higher subgroup: varenicline only; smoking cessation (≥ 6 month compared with reduction alone (moderate certainty).
Reduction and pharmacotherapy showed no clear difference in subgroup: bupropion only; smoking cessation (≥ 6 month compared with reduction alone (low certainty).