Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 3 · 42.9%Very low 4 · 57.1%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Reduced dose of antipsychotics vs antipsychotic maintenance

Tardive dyskinesia: No clinically important improvement · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia

It is very uncertain whether reduced dose of antipsychotics changes tardive dyskinesia: no clinically important improvement compared with antipsychotic maintenance (very low certainty).

1 finding from 1 review

Antipsychotic reduction and/or cessation and antipsychotics as specific treatments for tardive dyskinesia 2018 · Cochrane Headline outcomes only
RR 0.42 [0.17, 1.04]
2 studies · 17 participants
Very low

Reduced dose of antipsychotics vs antipsychotic maintenance

Tardive dyskinesia: Deterioration of symptoms · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia

It is very uncertain whether reduced dose of antipsychotics changes tardive dyskinesia: deterioration of symptoms compared with antipsychotic maintenance (very low certainty).

1 finding from 1 review

Antipsychotic reduction and/or cessation and antipsychotics as specific treatments for tardive dyskinesia 2018 · Cochrane Headline outcomes only
RR 0.61 [0.11, 3.31]
2 studies · 17 participants
Very low

Reduced dose of antipsychotics vs antipsychotic maintenance

General mental state: relapse · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia

It is very uncertain whether reduced dose of antipsychotics changes general mental state: relapse compared with antipsychotic maintenance (very low certainty).

1 finding from 1 review

Antipsychotic reduction and/or cessation and antipsychotics as specific treatments for tardive dyskinesia 2018 · Cochrane Headline outcomes only
RR 3 [0.16, 57.36]
1 study · 8 participants
Very low

Reduced dose of antipsychotics vs antipsychotic maintenance

Adverse effect: any ‐ not reported · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia

1 finding from 1 review

Antipsychotic reduction and/or cessation and antipsychotics as specific treatments for tardive dyskinesia 2018 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Reduced dose of antipsychotics vs antipsychotic maintenance

Adverse effect: extrapyramidal symptoms ‐ not reported · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia

1 finding from 1 review

Antipsychotic reduction and/or cessation and antipsychotics as specific treatments for tardive dyskinesia 2018 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Reduced dose of antipsychotics vs antipsychotic maintenance

Leaving the study early · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia

It is very uncertain whether reduced dose of antipsychotics changes acceptability of the treatment: leaving the study early compared with antipsychotic maintenance (very low certainty).

1 finding from 1 review

Antipsychotic reduction and/or cessation and antipsychotics as specific treatments for tardive dyskinesia 2018 · Cochrane Headline outcomes only
RR 0.33 [0.06, 1.99]
1 study · 8 participants
Very low

Reduced dose of antipsychotics vs antipsychotic maintenance

Social confidence, social inclusion, social networks, or personalised quality of life ‐ not reported · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia

1 finding from 1 review

Antipsychotic reduction and/or cessation and antipsychotics as specific treatments for tardive dyskinesia 2018 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported