Overall survival · children and young adults with diffuse brainstem glioma
Hyperfractionated radiotherapy showed no clear difference in overall survival compared with conventional radiotherapy (low certainty).
1 finding from 1 review
Progression‐free survival · children and young adults with diffuse brainstem glioma
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Event‐free survival · children and young adults with diffuse brainstem glioma
Hyperfractionated radiotherapy showed no clear difference in event‐free survival compared with conventional radiotherapy (low certainty).
1 finding from 1 review
Quality of life · children and young adults with diffuse brainstem glioma
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Neurological response · children and young adults with diffuse brainstem glioma
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Radiological response defined as the number of participants with a reduction in tumour size > 50% · children and young adults with diffuse brainstem glioma
It is very uncertain whether hyperfractionated radiotherapy changes radiological response defined as the number of participants with a… compared with conventional radiotherapy (very low certainty).
1 finding from 1 review
Toxicities · children and young adults with diffuse brainstem glioma
1 finding from 1 review
Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
Hyperfractionated radiotherapy led to lower locoregional control compared with conventional (standard) fractionation radiotherapy; GRADE not reported.
1 finding from 1 review
Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
Hyperfractionated radiotherapy led to lower total mortality compared with conventional (standard) fractionation radiotherapy; GRADE not reported.
1 finding from 1 review
Disease-free survival · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
1 finding from 1 review
Overall survival
It is very uncertain whether extended‐field chemoradiotherapy changes overall survival compared with pelvic chemoradiotherapy (very low certainty).
1 finding from 1 review
Para‐aortic lymph node recurrence
It is very uncertain whether extended‐field chemoradiotherapy changes para‐aortic lymph node recurrence compared with pelvic chemoradiotherapy (very low certainty).
1 finding from 1 review
Progression‐free survival
It is very uncertain whether extended‐field chemoradiotherapy changes progression‐free survival compared with pelvic chemoradiotherapy (very low certainty).
1 finding from 1 review
Acute adverse events
It is very uncertain whether extended‐field chemoradiotherapy changes acute adverse events compared with pelvic chemoradiotherapy (very low certainty).
1 finding from 1 review
Late adverse events
It is very uncertain whether extended‐field chemoradiotherapy changes late adverse events compared with pelvic chemoradiotherapy (very low certainty).
1 finding from 1 review
Altered fractionation radiotherapy vs Chemoradiotherapy (concurrent, standard fractionation)
Outcome not reported · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
The review found no eligible studies for this question.
1 finding from 1 review
Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
Accelerated/split-course radiotherapy showed no clear difference in total mortality compared with conventional (standard) fractionation radiotherapy; GRADE not reported.
1 finding from 1 review
Locoregional recurrence · Adults with oral cavity or oropharyngeal cancer
The review found no eligible studies for this question.
1 finding from 1 review
Total mortality · Adults with oral cavity or oropharyngeal cancer
It is very uncertain whether surgery plus radiotherapy changes total mortality compared with radiotherapy alone (very low certainty).
1 finding from 1 review
Disease-free survival · Adults with oral cavity or oropharyngeal cancer
The review found no eligible studies for this question.
1 finding from 1 review