Findings

What do systematic reviews say?

13 questions · 13 findings · 2 reviews · Schizophrenia

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 7.7%Low 3 · 23.1%Moderate 9 · 69.2%High 0 · 0%

QUETIAPINE vs CLOZAPINE ‐ all data short term

Adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson medication · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Low

QUETIAPINE vs OLANZAPINE

Adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson medication · schizophrenia

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1127 participants
Moderate

QUETIAPINE vs PALIPERIDONE

Adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson medication · schizophrenia

QUETIAPINE probably leads to lower adverse effects: 2. Extrapyramidal effects use of antiparkinson… compared with PALIPERIDONE (moderate certainty).

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.64 [0.45, 0.91]
1 study · 319 participants
Moderate

QUETIAPINE vs RISPERIDONE

Adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson medication · schizophrenia

QUETIAPINE probably leads to lower adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson… compared with RISPERIDONE (moderate certainty).

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.5 [0.36, 0.69]
8 studies · 2163 participants
Moderate

QUETIAPINE vs ZIPRASIDONE

Adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson medication · schizophrenia

QUETIAPINE may leads to lower adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson… compared with ZIPRASIDONE (low certainty).

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.43 [0.2, 0.93]
1 study · 522 participants
Low

QUETIAPINE vs ARIPIPRAZOLE

Adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson medication · schizophrenia

QUETIAPINE showed no clear difference in adverse effects: 2. Extrapyramidal effects ‐ use of antiparkinson… compared with ARIPIPRAZOLE (low certainty).

1 finding from 1 review

Quetiapine versus other atypical antipsychotics for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.67 [0.12, 3.57]
1 study · 40 participants
Low

QUETIAPINE vs Typical antipsychotics

Global state: No clinically significant response (as defined by the original studies) · patients with schizophrenia

Quetiapine showed no clear difference in global state No clinical significant response as defined by the… compared with typical antipsychotics (moderate certainty).

1 finding from 1 review

Quetiapine versus typical antipsychotic medications for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.96 [0.75, 1.23]
16 studies · 1607 participants
Moderate

QUETIAPINE vs Typical antipsychotics

Leaving the study early · patients with schizophrenia

Quetiapine showed no clear difference in leaving the study early due to any reason compared with typical antipsychotics (moderate certainty).

1 finding from 1 review

Quetiapine versus typical antipsychotic medications for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.91 [0.81, 1.01]
23 studies · 3576 participants
Moderate

QUETIAPINE vs Typical antipsychotics

Mental state: 2. Positive symptoms ‐ average endpoint score PANSS positive subscore · patients with schizophrenia

1 finding from 1 review

Quetiapine versus typical antipsychotic medications for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
22 studies · 1934 participants
Moderate

QUETIAPINE vs Typical antipsychotics

Mental state: 3. Negative symptoms ‐ average endpoint score PANSS negative subscore · patients with schizophrenia

1 finding from 1 review

Quetiapine versus typical antipsychotic medications for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
22 studies · 1934 participants
Moderate

QUETIAPINE vs Typical antipsychotics

Cognitive function · patients with schizophrenia

1 finding from 1 review

Quetiapine versus typical antipsychotic medications for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 142 participants
Very low

QUETIAPINE vs Typical antipsychotics

Adverse effects: unspecified extrapyramidal symptoms · patients with schizophrenia

Quetiapine probably leads to lower extrapyramidal effects compared with typical antipsychotics (moderate certainty).

1 finding from 1 review

Quetiapine versus typical antipsychotic medications for schizophrenia 2013 · Cochrane Headline outcomes only
RR 0.17 [0.09, 0.32]
8 studies · 1095 participants
Moderate

QUETIAPINE vs Typical antipsychotics

Prolactin level Average level in ng/mL · patients with schizophrenia

1 finding from 1 review

Quetiapine versus typical antipsychotic medications for schizophrenia 2013 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 1034 participants
Moderate