Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

25 questions · 26 findings · 4 reviews

No studies found 6 · 23.1%GRADE not reported 4 · 15.4%Very low 0 · 0%Low 11 · 42.3%Moderate 1 · 3.8%High 4 · 15.4%

Pyridoxine vs control

Pre‐eclampsia · pregnant women, either during the prenatal period or during labour.

Pyridoxine (B6) showed no clear difference in pre‐eclampsia ‐ Antenatal oral pyridoxine versus control compared with control (low certainty).

2 findings from 1 review

Pyridoxine vs control

Dental decay (increase in decayed, missing or filled teeth) ‐ Antenatal pyridoxine lozenges versus control · pregnant women, either during the prenatal period or during labour.

Pyridoxine (B6) may leads to lower dental decay (increase in decayed, missing or filled teeth) ‐… compared with control (low certainty).

1 finding from 1 review

Pyridoxine vs placebo

Dizziness · Pregnant women with hyperemesis gravidarum

Pyridoxine showed no clear difference in interventions side effects: dizziness compared with placebo (low certainty).

1 finding from 1 review

Pyridoxine vs placebo

Adverse effects: headache · Pregnant women with hyperemesis gravidarum

Pyridoxine showed no clear difference in interventions side effects: headaches compared with placebo (low certainty).

1 finding from 1 review

Pyridoxine vs placebo

Interventions side effects: diarrhoea · Pregnant women with hyperemesis gravidarum

Pyridoxine showed no clear difference in interventions side effects: diarrhoea compared with placebo; GRADE not reported.

1 finding from 1 review

Pyridoxine vs placebo

Adverse effects: palpitations · Pregnant women with hyperemesis gravidarum

Pyridoxine showed no clear difference in interventions side effects: palpitations compared with placebo (low certainty).

1 finding from 1 review

Pyridoxine vs placebo

Adverse effects: dry mouth · Pregnant women with hyperemesis gravidarum

Pyridoxine showed no clear difference in interventions side effects: dry mouth compared with placebo (low certainty).

1 finding from 1 review

Pyridoxine vs placebo

Severity, reduction or cessation in nausea/vomiting 2. Quality of life outcomes 3. Pregnancy complications 4. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review