Findings

What do systematic reviews say?

5 questions · 5 findings · 2 reviews

No studies found 1 · 20%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 80%High 0 · 0%

Adverse events · patients with functional dyspepsia

Proton pump inhibitors (PPI) showed no clear difference in adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Proton pump inhibitors for functional dyspepsia 2017 · Cochrane Headline outcomes only
RR 0.99 [0.73, 1.33]
6 studies · 2693 participants
Moderate

Adverse events · adults with functional dyspepsia

Proton pump inhibitors (PPI) showed no clear difference in adverse events compared with H2 receptor antagonists (H2RA) (moderate certainty).

1 finding from 1 review

Proton pump inhibitors for functional dyspepsia 2017 · Cochrane Headline outcomes only
RR 0.97 [0.64, 1.46]
1 study · 589 participants
Moderate

Adverse events · adults with functional dyspepsia

Proton pump inhibitors (PPI) showed no clear difference in adverse events compared with prokinetics (moderate certainty).

1 finding from 1 review

Proton pump inhibitors for functional dyspepsia 2017 · Cochrane Headline outcomes only
RR 1.09 [0.79, 1.49]
5 studies · 1033 participants
Moderate

Adverse events · adults with functional dyspepsia

Proton pump inhibitors plus prokinetics probably leads to lower adverse events compared with prokinetics alone (moderate certainty).

1 finding from 1 review

Proton pump inhibitors for functional dyspepsia 2017 · Cochrane Headline outcomes only
RR 0.6 [0.39, 0.93]
2 studies · 407 participants
Moderate

Serious adverse events · people admitted to intensive care units

The review found no eligible studies for this question.

1 finding from 1 review