Findings

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5 questions · 5 findings · 1 reviews · Gut

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 80%Moderate 1 · 20%High 0 · 0%

Proton pump inhibitors (PPI) vs H2RA, placebo or no treatment

Endoscopic haemostatic treatment at index endoscopy · people with upper gastrointestinal bleeding prior to endoscopic diagnosis

Proton pump inhibitor treatment probably leads to lower endoscopic haemostatic treatment at index endoscopy compared with H2RA, placebo or no treatment (moderate certainty).

1 finding from 1 review

Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding 2022 · Cochrane Headline outcomes only
OR 0.68 [0.5, 0.93]
3 studies · 1983 participants
Moderate

Proton pump inhibitors (PPI) vs H2RA, placebo or no treatment

Mortality ‐ within 30 days · people with upper gastrointestinal bleeding prior to endoscopic diagnosis

Proton pump inhibitor treatment showed no clear difference in mortality ‐ within 30 days compared with H2RA, placebo or no treatment (low certainty).

1 finding from 1 review

Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding 2022 · Cochrane Headline outcomes only
OR 1.14 [0.76, 1.7]
5 studies · 2143 participants
Low

Proton pump inhibitors (PPI) vs H2RA, placebo or no treatment

Rebleeding · people with upper gastrointestinal bleeding prior to endoscopic diagnosis

Proton pump inhibitor treatment showed no clear difference in rebleeding ‐ within 30 days compared with H2RA, placebo or no treatment (low certainty).

1 finding from 1 review

Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding 2022 · Cochrane Headline outcomes only
OR 0.81 [0.62, 1.06]
5 studies · 2121 participants
Low

Proton pump inhibitors (PPI) vs H2RA, placebo or no treatment

Surgery ‐ within 30 days · people with upper gastrointestinal bleeding prior to endoscopic diagnosis

Proton pump inhibitor treatment showed no clear difference in surgery ‐ within 30 days compared with H2RA, placebo or no treatment (low certainty).

1 finding from 1 review

Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding 2022 · Cochrane Headline outcomes only
OR 0.91 [0.65, 1.26]
6 studies · 2223 participants
Low

Proton pump inhibitors (PPI) vs H2RA, placebo or no treatment

Proportion of participants with stigmata of recent haemorrhage at index endoscopy · people with upper gastrointestinal bleeding prior to endoscopic diagnosis

Proton pump inhibitor treatment showed no clear difference in proportion of participants with stigmata of recent haemorrhage at… compared with H2RA, placebo or no treatment (low certainty).

1 finding from 1 review

Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding 2022 · Cochrane Headline outcomes only
OR 0.8 [0.52, 1.21]
4 studies · 1332 participants
Low