Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 1 · 33.3%Moderate 0 · 0%High 1 · 33.3%

Amputation · people with critical limb ischaemia

Prostanoids showed no clear difference in total amputations compared with naftidrofuryl (low certainty).

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
RR 0.96 [0.57, 1.64]
1 study · 29 participants
Low

Amputation · people with critical limb ischaemia

Prostanoids showed no clear difference in total amputations compared with placebo (high certainty).

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
RR 0.97 [0.86, 1.09]
12 studies · 2825 participants
High

Amputation · people with critical limb ischaemia

It is very uncertain whether prostanoids changes total amputations compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
RR 0.5 [0.05, 5.27]
1 study · 70 participants
Very low