Findings

What do systematic reviews say?

24 questions · 25 findings · 4 reviews

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No studies found 12 · 48%GRADE not reported 5 · 20%Very low 3 · 12%Low 3 · 12%Moderate 2 · 8%High 0 · 0%

Oral propranolol vs placebo

Change in pain index · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral propranolol (beta-blocker) showed no clear difference in change in pain index compared with placebo; GRADE not reported.

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
1 week per period (cross-over)
Tchivileva et al 2010: statistically significant difference in reduction in pain index between the propranolol treatment period and the placebo treatment period (P = 0.02).
1 study · 40 participants
GRADE not reported

Oral propranolol vs placebo

Reduction in pain intensity · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral propranolol (beta-blocker) led to lower reduction in pain intensity (percentage of patients responding) compared with placebo; GRADE not reported.

2 findings from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
1 week per period (cross-over)
Tchivileva et al 2010: a significantly greater percentage of patients (67.5% versus 32.5%) experienced reduction in pain intensity rating during the propranolol treatment period than the placebo treatment period (P =…
1 study · 40 participants
GRADE not reported
Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
1 week per period (cross-over)
Tchivileva et al 2010: Reduction in pain intensity rating (primary outcome) comparing propranolol treatment to placebo treatment did not reach statistical significance (P = 0.104); pairwise differences between…
1 study · 40 participants
GRADE not reported

Oral propranolol vs placebo

Reduction in pain duration (percentage of day) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral propranolol (beta-blocker) showed no clear difference in reduction in pain duration (percentage of day) compared with placebo; GRADE not reported.

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
1 week per period (cross-over)
Tchivileva et al 2010: no statistically significant difference in reduction in pain duration (P = 0.802) between propranolol and placebo.
1 study · 40 participants
GRADE not reported

Oral propranolol vs placebo

Adverse events ‐ treatment emergent · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
1 week per period (cross-over)
Tchivileva et al 2010: at least one treatment-emergent adverse event was reported by five participants (12.5%) during the propranolol period (nausea, diarrhoea, insomnia, dizziness, fatigue) and four participants (10%)…
1 study · 40 participants
GRADE not reported