What do systematic reviews say?

Prophylactic levosimendan vs usual care

Prophylactic levosimendan showed no clear difference in mortality compared with standard treatment (low certainty).

• Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients… 2017 · Cochrane Headline outcomes only
  RR 0.47 [0.12, 1.82]
  3 studies · 123 participants
  Low

Prophylactic levosimendan vs usual care

Prophylactic levosimendan showed no clear difference in low cardiac output syndrome (LCOS) compared with standard treatment (low certainty).

• Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients… 2017 · Cochrane Headline outcomes only
  RR 0.64 [0.39, 1.04]
  2 studies · 83 participants
  Low

Prophylactic levosimendan vs usual care

• Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 188 participants
  Low

Prophylactic levosimendan vs usual care

• Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 75 participants
  Low

Prophylactic levosimendan vs usual care

• Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 208 participants
  Low

Prophylactic levosimendan vs usual care

Prophylactic levosimendan showed no clear difference in mechanical circulatory support or cardiac transplantation compared with standard treatment (low certainty).

• Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients… 2017 · Cochrane Headline outcomes only
  RR 1.49 [0.19, 11.37]
  2 studies · 60 participants
  Low