What do systematic reviews say?

Prophylactic antibiotics vs placebo

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Prophylactic antibiotics vs placebo

Prophylactic antibiotics showed no clear difference in preterm prelabour rupture of membranes compared with placebo (low certainty).

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  RR 0.31 [0.06, 1.49]
  1 study · 229 participants
  Low

Prophylactic antibiotics vs placebo

Prophylactic antibiotics may leads to lower prelabour rupture of membranes compared with placebo (low certainty).

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  RR 0.34 [0.15, 0.78]
  1 study · 229 participants
  Low

Prophylactic antibiotics vs placebo

Prophylactic antibiotics showed no clear difference in preterm delivery compared with placebo (high certainty).

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  RR 0.88 [0.72, 1.09]
  6 studies · 3663 participants
  High

Prophylactic antibiotics vs placebo

It is very uncertain whether prophylactic antibiotics changes chorioamnionitis compared with placebo (very low certainty).

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  RR 0.62 [0.1, 3.62]
  1 study · 229 participants
  Very low

Prophylactic antibiotics vs placebo

Prophylactic antibiotics probably leads to lower puerperal sepsis/postpartum endometritis compared with placebo (moderate certainty).

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  RR 0.53 [0.35, 0.82]
  3 studies · 627 participants
  Moderate