Findings

What do systematic reviews say?

8 questions · 12 findings · 2 reviews · Gynaecology and Fertility

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No studies found 4 · 33.3%GRADE not reported 0 · 0%Very low 3 · 25%Low 5 · 41.7%Moderate 0 · 0%High 0 · 0%

Oral progestogen (dienogest, desogestrel) vs goserelin acetate

Uterine fibroid‐related symptoms (duration of uterine bleeding, measured at 12 weeks; lower = better) · women with uterine fibroids

1 finding from 1 review

Progestogens or progestogen‐releasing intrauterine systems for uterine fibroids (other than preoperative medical… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Very low

Oral progestogen (dienogest, desogestrel) vs goserelin acetate

Uterine fibroid‐related symptoms (abnormal uterine bleeding, measured at 12 weeks, with the pictorial blood assessment chart (PBAC); lower = better) · women with uterine fibroids

1 finding from 1 review

Progestogens or progestogen‐releasing intrauterine systems for uterine fibroids (other than preoperative medical… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Very low

Oral progestogen (dienogest, desogestrel) vs goserelin acetate

Fibroid size · women with uterine fibroids

The review found no eligible studies for this question.

1 finding from 1 review

Progestogens or progestogen‐releasing intrauterine systems for uterine fibroids (other than preoperative medical… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral progestogen (dienogest, desogestrel) vs goserelin acetate

Adverse events (hot flushes) · women with uterine fibroids

1 finding from 1 review

Progestogens or progestogen‐releasing intrauterine systems for uterine fibroids (other than preoperative medical… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Very low

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

Live birth or ongoing pregnancy · ovarian stimulation protocols for women undergoing ART

Progestogen showed no clear difference in live birth or ongoing pregnancy (Prog + Ant vs Ant) compared with placebo or no pretreatment (low certainty).

2 findings from 1 review

Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
OR 0.67 [0.18, 2.54]
1 study · 47 participants
Low
Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
OR 1.35 [0.69, 2.65]
2 studies · 222 participants
Low

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

Pregnancy loss · ovarian stimulation protocols for women undergoing ART

Progestogen showed no clear difference in pregnancy loss (Prog + Ag vs Ag) compared with placebo or no pretreatment (low certainty).

2 findings from 1 review

Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
OR 2.26 [0.67, 7.55]
2 studies · 222 participants
Low
Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
OR 0.36 [0.06, 2.09]
1 study · 47 participants
Low

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

Multiple pregnancy rate · ovarian stimulation protocols for women undergoing ART

The review found no eligible studies for this question.

2 findings from 1 review

Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
OR 1.05 [0.06, 17.76]
1 study · 47 participants
Low

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

OHSS · ovarian stimulation protocols for women undergoing ART

The review found no eligible studies for this question.

2 findings from 1 review

Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found