Findings

What do systematic reviews say?

3 questions · 4 findings · 1 reviews · Dental caries

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No studies found 0 · 0%GRADE not reported 4 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries in children · Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy

Prenatal vitamin D deficiency is associated with significantly higher odds of dental caries in children (pooled OR 1.35, 95% CI 1.22-1.47), but heterogeneity is high (I2=86.6%) and publication bias is present; the observational evidence is ungraded.

2 findings from 1 review

Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and… 2024 All outcomes
Prenatal exposure; dental caries assessed in children aged 2 to 8 years · Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey) · Overall (all studies pooled)
OR 1.35 [1.22, 1.47]
12 studies · 11021 participants
GRADE not reported
Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and… 2024 All outcomes
Prenatal exposure; dental caries in children aged 2 to 8 years · Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey) · Publication-bias adjustment: Trim & Fill corrected pooled estimate
OR 1.28 [1.14, 1.48]
Studies not reported
GRADE not reported

Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries in children · Children aged 6 to 8 years whose mothers' prenatal vitamin D status was assessed

In the single study of children aged 6-8 years, the association was not statistically significant (OR 1.07, 95% CI 0.84-1.30); ungraded.

1 finding from 1 review

Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and… 2024 All outcomes
Prenatal exposure; dental caries at 6 to 8 years · Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey) · Children's age subgroup: 6 to 8 years
OR 1.07 [0.84, 1.30]
1 study
GRADE not reported

Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries in children · Children aged 4 to 6 years whose mothers' prenatal vitamin D status was assessed

Among children aged 4-6 years, prenatal vitamin D deficiency is associated with significantly higher odds of dental caries (OR 1.44, 95% CI 1.32-1.56); ungraded.

1 finding from 1 review

Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and… 2024 All outcomes
Prenatal exposure; dental caries at 4 to 6 years · Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey) · Children's age subgroup: 4 to 6 years
OR 1.44 [1.32, 1.56]
8 studies
GRADE not reported