Findings

What do systematic reviews say?

2 questions · 4 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 25%High 3 · 75%

IVIg vs placebo or no intervention

28‐Day all cause mortality (adult studies) · adult patients with sepsis, severe sepsis and septic shock

Polyclonal intravenous immunoglobulin (IVIG) showed no clear difference in low risk of bias adult studies, by type of polyclonal IVIG,… compared with placebo or no intervention (high certainty).

3 findings from 1 review

Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock 2013 · Cochrane Headline outcomes only
RR 0.97 [0.81, 1.15]
5 studies · 945 participants
High
Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock 2013 · Cochrane Headline outcomes only
RR 1.02 [0.84, 1.24]
3 studies · 683 participants
High
Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock 2013 · Cochrane Headline outcomes only
RR 0.82 [0.56, 1.19]
2 studies · 262 participants
Moderate

IVIg vs placebo or no intervention

All‐cause mortality, neonates, standard polyclonal IVIG · neonates with sepsis, severe sepsis and septic shock

Polyclonal intravenous immunoglobulin (IVIG) showed no clear difference in low risk of bias neonate studies, mortality all‐cause ‐ standard IVIG compared with placebo or no intervention (high certainty).

1 finding from 1 review

Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock 2013 · Cochrane Headline outcomes only
RR 1.01 [0.93, 1.09]
3 studies · 3561 participants
High