What do systematic reviews say?

Autologous platelet‐rich plasma vs placebo or no treatment

It is very uncertain whether platelet rich plasma changes presence of dry socket compared with placebo or no treatment (very low certainty).

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Follow-up: median 7 days
  RR 0.51 [0.19, 1.33]
  2 studies · 127 participants
  Very low

Autologous platelet‐rich plasma vs placebo or no treatment

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Follow-up: median 7 days
  No adverse events were reported in these two trials.
  2 studies
  GRADE not reported

Bone graft with platelet-rich plasma (PRP) vs Bone graft without PRP

• Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes

  2 years after loading
  Raghoebar 2005: 1 complication in the non-PRP arm, OR 0.27 (0.01 to 8.46), P = 0.46; Torres 2009 (PRP only = 3, no-PRP only = 2), OR 1.49 (0.15 to 15.07), P = 1.00. No statistically significant difference.
  2 studies · 62 participants
  GRADE not reported

Bone graft with platelet-rich plasma (PRP) vs Bone graft without PRP

• Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes

  2 years after loading
  No statistically significant difference for implant failures. Per trial: Raghoebar 2005 1 failure in the PRP arm, OR 3.67 (0.12 to 113.73), P = 0.46; Torres 2009 (PRP only = 1, no-PRP only = 2), OR 0.50 (0.01 to…
  2 studies · 62 participants
  GRADE not reported

Bone graft with platelet-rich plasma (PRP) vs Bone graft without PRP

Bone graft with platelet-rich plasma (PRP) showed no clear difference in partial graft loss compared with bone graft without PRP; GRADE not reported.

• Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes

  2 years after loading
  OR 1.5 [0.17, 17.96]
  1 study · 57 participants
  GRADE not reported

PRP (platelet-rich plasma) in cellulose foam placed in extraction socket vs placebo, no treatment or surveillance only

It is very uncertain whether PRP (platelet-rich plasma) in cellulose foam placed in extraction… changes incidence of ORN compared with no treatment/placebo (cellulose foam only) placed in extraction socket (very low certainty).

• Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes

  5-year follow-up
  OR 3.32 [0.58, 19.09]
  1 study · 44 participants
  Very low

PRP (platelet-rich plasma) in cellulose foam placed in extraction socket vs placebo, no treatment or surveillance only

• Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes

  2 weeks to 12 months
  This comparison was only made in 1 study: mean pain scores at 2 weeks, 2, 6, 9, and 12 months showed no 'significant' differences between the 2 groups (self-reported Likert scale 1 to 10; difference at 2 weeks P =…
  1 study · 44 participants
  Very low

Two-stage sinus lift + buccal onlay iliac grafts WITH platelet-rich plasma (PRP) vs Same grafts WITHOUT PRP (split-mouth)

• Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant… 2009 · Cochrane All outcomes

  2 years post-loading
  No statistically significant difference for any outcome; data not shown (Raghoebar 2005)
  1 study · 5 participants
  GRADE not reported