Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%

Phentermine/topiramate vs placebo

Serious adverse events · Men and non‐pregnant women ≥ 18 years old with essential hypertension

Phentermine/topiramate showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Long‐term effects of weight‐reducing drugs in people with hypertension 2021 · Cochrane Headline outcomes only
RR 0.85 [0.49, 1.48]
1 study · 1305 participants
Low

Phentermine/topiramate vs placebo

All adverse events · Men and non‐pregnant women ≥ 18 years old with essential hypertension

Phentermine/topiramate may leads to higher all adverse events compared with placebo (low certainty).

1 finding from 1 review

Long‐term effects of weight‐reducing drugs in people with hypertension 2021 · Cochrane Headline outcomes only
RR 1.13 [1.08, 1.2]
1 study · 1305 participants
Low

Phentermine/topiramate vs placebo

Change in systolic blood pressure as compared to placebo [mm Hg] from baseline to end of study · Men and non‐pregnant women ≥ 18 years old with essential hypertension

1 finding from 1 review

Long‐term effects of weight‐reducing drugs in people with hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 772 participants
Low

Phentermine/topiramate vs placebo

Change in diastolic blood pressure as compared to placebo [mm Hg] from baseline to end of study · Men and non‐pregnant women ≥ 18 years old with essential hypertension

1 finding from 1 review

Long‐term effects of weight‐reducing drugs in people with hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 772 participants
Low

Phentermine/topiramate vs placebo

Change in body weight as compared to placebo (%) from baseline to end of study · Men and non‐pregnant women ≥ 18 years old with essential hypertension

1 finding from 1 review

Long‐term effects of weight‐reducing drugs in people with hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 772 participants
Low

Phentermine/topiramate vs placebo

Total mortality · Men and non‐pregnant women ≥ 18 years old with essential hypertension

1 finding from 1 review

Long‐term effects of weight‐reducing drugs in people with hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1305 participants
Low

Phentermine/topiramate vs placebo

Cardiovascular morbidity · Men and non‐pregnant women ≥ 18 years old with essential hypertension

1 finding from 1 review

Long‐term effects of weight‐reducing drugs in people with hypertension 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1305 participants
Very low