What do systematic reviews say?

Perioperative chemotherapy vs primary surgery

Perioperative chemotherapy leads to lower overall survival by tumor site ‐ GE junction compared with primary surgery (high certainty).

• Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach,… 2013 · Cochrane Headline outcomes only
  HR 0.69 [0.54, 0.87]
  6 studies · 470 participants
  High