What do systematic reviews say?

Paracetamol 1000 mg vs placebo

• Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  High

Paracetamol 1000 mg vs placebo

• Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate
• Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate

Paracetamol 1000 mg vs placebo

• Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate

Paracetamol 1000 mg vs placebo

• Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  High

Paracetamol 1000 mg vs placebo

• Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  High

Paracetamol 1000 mg vs placebo

• Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Combined paracetamol plus ibuprofen in a single tablet (e.g.… showed no clear difference in proportion of patients with >50% maximum pain relief (TOTPAR) over 2… compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (moderate certainty).

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  2 hours postdosing · Paracetamol 1000 mg/ibuprofen 400 mg vs paracetamol 1000 mg or ibuprofen 400 mg
  RR 1.29 [0.91, 1.85]
  1 study · 170 participants
  Moderate

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  Study period (immediate postoperative)
  The majority of adverse events were minor in nature and usually included nausea, vomiting, headaches and dizziness. Side effect profiles have not been included in a meta-analysis as multiple adverse events were…
  2 studies
  GRADE not reported

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Combined paracetamol plus ibuprofen in a single tablet (e.g.… probably leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 6… compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (moderate certainty).

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  6 hours postdosing · Paracetamol 1000 mg/ibuprofen 400 mg vs paracetamol 1000 mg or ibuprofen 400 mg
  RR 1.77 [1.32, 2.39]
  1 study · 170 participants
  Moderate

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Combined paracetamol plus ibuprofen in a single tablet (e.g.… leads to higher patients not using rescue medication at 8 hours compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (high certainty).

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  8 hours postdosing · Paracetamol 1000/500 mg/ibuprofen 400/200 mg vs single constituent drugs
  RR 1.60 [1.36, 1.88]
  2 studies · 467 participants
  High