Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

13 questions · 13 findings · 2 reviews

No studies found 1 · 7.7%GRADE not reported 0 · 0%Very low 0 · 0%Low 11 · 84.6%Moderate 1 · 7.7%High 0 · 0%

PUFA vs placebo

50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐ Older (19 years or more) · patients with drug‐resistant epilepsy

PUFA showed no clear difference in 50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐… compared with placebo (low certainty).

1 finding from 1 review

PUFA vs placebo

50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐ Younger (< 19 years) · patients with drug‐resistant epilepsy

PUFA may leads to higher 50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐… compared with placebo (low certainty).

1 finding from 1 review

LCPUFA supplemented formula vs control formula

Sweep VEP acuity at 12 months (LogMAR) ‐ DHA and AA vs normal term formula · term infants

LCPUFA supplemented formula showed no clear difference in sweep VEP acuity at 12 months (LogMAR) ‐ DHA and AA vs normal term… compared with control formula (low certainty).

1 finding from 1 review

LCPUFA supplemented formula vs control formula

Head circumference at 12 months (z scores) ‐ DHA and AA vs normal term formula · term infants

LCPUFA supplemented formula showed no clear difference in head circumference at 12 months (z scores) ‐ DHA and AA vs normal… compared with control formula (low certainty).

1 finding from 1 review