What do systematic reviews say?

High levels of PEEP vs low levels of PEEP

High levels of PEEP showed no clear difference in barotrauma compared with low levels of PEEP (low certainty).

• High versus low positive end‐expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute… 2021 · Cochrane Headline outcomes only
  RR 1 [0.64, 1.57]
  9 studies · 3791 participants
  Low