P11-4 + fluoride varnish vs Placebo or no active treatment
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Combined self-assembling peptide P11-4 plus fluoride varnish significantly improved white spot lesion remineralization versus control (SMD -0.96, 95% CI -1.44 to -0.48) and ranked highest of seven therapies by SUCRA (89.7%); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
- Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. 2023 All outcomesRCTs (clinical and in vitro); predominantly children and adolescents; orthodontic and non-orthodontic white spot lesions, early caries lesions, and artificial lesionsSMD -0.96 [-1.44, -0.48]1 studyGRADE not reported