What do systematic reviews say?

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- P11-4 + fluoride varnish vs CPP-ACP · Change in lesion metric measured by QLF, laser fluorescence, or lesion area
  Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. 2023 All outcomes
  2 weeks to 36 months · Clinical and in vitro
  SMD -0.78 [-1.33, -0.24]
  Studies not reported
  GRADE not reported

P11-4 + fluoride varnish vs CPP-ACP

Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · People or specimens with white spot lesions or early caries lesions

The NMA estimated an SMD of -0.78 for P11-4 + fluoride varnish versus CPP-ACP (95% CI -1.33 to -0.28).

1 finding from 1 review

Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. 2023 All outcomes
2 weeks to 36 months · Clinical and in vitro
SMD -0.78 [-1.33, -0.24]
Studies not reported
GRADE not reported