What do systematic reviews say?

Ozone vs antibiotic treatments

Ozone showed no clear difference in number of ulcers healed compared with antibiotic treatments (low certainty).

• Ozone therapy for treating foot ulcers in people with diabetes 2015 · Cochrane Headline outcomes only
  RR 1.1 [0.87, 1.4]
  1 study · 100 participants
  Low

Ozone vs antibiotic treatments

• Ozone therapy for treating foot ulcers in people with diabetes 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  Low

Ozone vs antibiotic treatments

• Ozone therapy for treating foot ulcers in people with diabetes 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  Low

Ozone + usual care vs sham ozone + usual care

Ozone + usual care showed no clear difference in number of ulcers healed compared with sham ozone + usual care (low certainty).

• Ozone therapy for treating foot ulcers in people with diabetes 2015 · Cochrane Headline outcomes only
  RR 1.69 [0.9, 3.17]
  2 studies · 111 participants
  Low

Ozone + usual care vs sham ozone + usual care

• Ozone therapy for treating foot ulcers in people with diabetes 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 111 participants
  Very low

Ozone + usual care vs sham ozone + usual care

Ozone + usual care showed no clear difference in adverse events/complications compared with sham ozone + usual care (low certainty).

• Ozone therapy for treating foot ulcers in people with diabetes 2015 · Cochrane Headline outcomes only
  RR 2.27 [0.48, 10.79]
  1 study · 61 participants
  Low

Ozone + usual care vs sham ozone + usual care

Ozone + usual care showed no clear difference in amputation compared with sham ozone + usual care (low certainty).

• Ozone therapy for treating foot ulcers in people with diabetes 2015 · Cochrane Headline outcomes only
  RR 2.73 [0.12, 64.42]
  1 study · 61 participants
  Low

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes

  To 6 months
  Baysan 2003 stated that no adverse events were reported to 6 months; no information was provided by Abu-Naba'a 2003 or Abu-Naba'a 2003pilot.
  1 study
  GRADE not reported

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
  Abu-Naba'a 2003 reported participants' state of anxiety, comparing ozone treatment with traditional dental interventions (injection, drilling, filling); because no participant was randomised between ozone and drilling…
  1 study
  GRADE not reported

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

The review found no eligible studies for this question.

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
  Data were not provided by any study on the number of lesions requiring restorations to 6 months or later; no data on any further conventional treatment or other dental interventions.
  Studies not reported
  No studies found

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

The review found no eligible studies for this question.

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
  No data were provided in any of the included trials on costs.
  Studies not reported
  No studies found

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

The review found no eligible studies for this question.

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
  No data were provided in any of the included trials on pain.
  Studies not reported
  No studies found

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes

  6 and 12 months
  No consistent trend of benefit or harm following ozone was seen across the outcome measures in any of the three studies; analyses were conducted at the lesion level (not independent of the person), so data were not…
  3 studies · 137 participants
  GRADE not reported

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

The review found no eligible studies for this question.

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
  No data were provided in any of the included trials on time to intervention.
  Studies not reported
  No studies found

Gaseous ozone vs placebo or control

Gaseous ozone showed no clear difference in presence of dry socket compared with placebo or control; GRADE not reported.

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Follow-up: median 7 days
  RR 0.20 [0.02, 1.61]
  1 study · 60 participants
  GRADE not reported