Findings

What do systematic reviews say?

22 questions · 22 findings · 3 reviews · Headline outcomes only

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No studies found 3 · 13.6%GRADE not reported 3 · 13.6%Very low 0 · 0%Low 5 · 22.7%Moderate 8 · 36.4%High 3 · 13.6%

Oral azithromycin vs control

Ocular chlamydia trachomatis infection · people (any age) with active trachoma

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral azithromycin vs control

Antibiotic resistance · people (any age) with active trachoma

Oral azithromycin led to lower antibiotic resistance Proportion of samples showing evidence of… compared with control; GRADE not reported.

1 finding from 1 review

Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 1354 participants
GRADE not reported

Oral azithromycin vs control

Adverse effects · people (any age) with active trachoma

1 finding from 1 review

Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 3069 participants
GRADE not reported

Oral azithromycin vs topical tetracycline

Active trachoma · people (any age) with active trachoma

1 finding from 1 review

Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 6002 participants
Low

Oral azithromycin vs topical tetracycline

Ocular chlamydia trachomatis infection · people (any age) with active trachoma

1 finding from 1 review

Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 5773 participants
Low

Oral azithromycin vs topical tetracycline

Antibiotic resistance · people (any age) with active trachoma

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral azithromycin vs topical tetracycline

Adverse effects · people (any age) with active trachoma

1 finding from 1 review

Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 6002 participants
GRADE not reported

Oral azithromycin vs control

Active trachoma · people (any age) with active trachoma

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral azithromycin vs placebo

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

1 finding from 1 review

Macrolide antibiotics (including azithromycin) for cystic fibrosis 2024 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 549 participants
High

Oral azithromycin vs placebo

Time to next pulmonary exacerbation · adults and children with cystic fibrosis

1 finding from 1 review

Macrolide antibiotics (including azithromycin) for cystic fibrosis 2024 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 796 participants
Moderate

Oral azithromycin vs placebo

Adverse events: number of mild treatment‐related adverse events · adults and children with cystic fibrosis

1 finding from 1 review

Macrolide antibiotics (including azithromycin) for cystic fibrosis 2024 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 748 participants
Moderate

Oral azithromycin vs placebo

Hospital admissions · adults and children with cystic fibrosis

1 finding from 1 review

Macrolide antibiotics (including azithromycin) for cystic fibrosis 2024 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 445 participants
High

Oral azithromycin vs placebo

New acquisition of CF pathogens: PA · adults and children with cystic fibrosis

1 finding from 1 review

Macrolide antibiotics (including azithromycin) for cystic fibrosis 2024 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 282 participants
Moderate

Oral azithromycin vs placebo

Need for additional antibiotics: participants needing extra IV antibiotics · adults and children with cystic fibrosis

1 finding from 1 review

Macrolide antibiotics (including azithromycin) for cystic fibrosis 2024 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 527 participants
High

Oral azithromycin vs placebo

QoL · adults and children with cystic fibrosis

1 finding from 1 review

Macrolide antibiotics (including azithromycin) for cystic fibrosis 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 177 participants
Moderate

Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo

Eradication of P aeruginosa from the respiratory tract: number of participants eradicated after three month treatment phase · children with cystic fibrosis and a new culture positive for P aeruginosa

Inhaled tobramycin (TNS) plus oral azithromycin showed no clear difference in eradication of P aeruginosa from the respiratory tract: number of… compared with TNS plus oral placebo (low certainty).

1 finding from 1 review

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
RR 1.01 [0.75, 1.35]
1 study · 91 participants
Low

Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo

FEV1 (% predicted): mean change from baseline · children with cystic fibrosis and a new culture positive for P aeruginosa

1 finding from 1 review

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 132 participants
Low

Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo

FVC (% predicted) Change from baseline · children with cystic fibrosis and a new culture positive for P aeruginosa

1 finding from 1 review

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
18 participants
Low

Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo

Change in weight (kg) · children with cystic fibrosis and a new culture positive for P aeruginosa

1 finding from 1 review

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 221 participants
Moderate

Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo

Frequency of infective pulmonary exacerbations: number of participants experiencing an exacerbation · children with cystic fibrosis and a new culture positive for P aeruginosa

Inhaled tobramycin (TNS) plus oral azithromycin showed no clear difference in frequency of infective pulmonary exacerbations: number of… compared with TNS plus oral placebo (moderate certainty).

1 finding from 1 review

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
RR 0.75 [0.56, 1]
1 study · 221 participants
Moderate