Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

91 questions · 96 findings · 8 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 42 · 43.8%GRADE not reported 0 · 0%Very low 13 · 13.5%Low 14 · 14.6%Moderate 18 · 18.8%High 9 · 9.4%

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Quality of life: CFQ‐R respiratory domain: absolute change from baseline · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen
1 finding from 1 review

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Exacerbation frequency · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Adverse effects of treatment · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

Oral plus nebulised antibiotics showed no clear difference in adverse effects of treatment compared with oral antibiotics plus nebulised placebo (low certainty).

1 finding from 1 review

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Eradication of MRSA · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

Oral plus nebulised antibiotics showed no clear difference in eradication of MRSA compared with oral antibiotics plus nebulised placebo (low certainty).

1 finding from 1 review

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Time until next positive MRSA isolate (from clinically relevant respiratory culture) · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) plus oral ciprofloxacin

Eradication of P aeruginosa from the respiratory tract: proportion with positive respiratory culture for P aeruginosa · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Inhaled colistin plus oral ciprofloxacin showed no clear difference in eradication of P aeruginosa from the respiratory tract: proportion… compared with inhaled tobramycin (TNS) plus oral ciprofloxacin (low certainty).

1 finding from 1 review

Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) plus oral ciprofloxacin

FEV1 % predicted: relative change from baseline · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) plus oral ciprofloxacin

Growth and nutritional status · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) plus oral ciprofloxacin

Frequency of infective pulmonary exacerbations: number of exacerbations per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) plus oral ciprofloxacin

Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
1 finding from 1 review

Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo

Eradication of P aeruginosa from the respiratory tract: number of participants eradicated after three month treatment phase · children with cystic fibrosis and a new culture positive for P aeruginosa

Inhaled tobramycin (TNS) plus oral azithromycin showed no clear difference in eradication of P aeruginosa from the respiratory tract: number of… compared with TNS plus oral placebo (low certainty).

1 finding from 1 review

Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo

Frequency of infective pulmonary exacerbations: number of participants experiencing an exacerbation · children with cystic fibrosis and a new culture positive for P aeruginosa

Inhaled tobramycin (TNS) plus oral azithromycin showed no clear difference in frequency of infective pulmonary exacerbations: number of… compared with TNS plus oral placebo (moderate certainty).

1 finding from 1 review

Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo

Isolation of other micro‐organisms from the respiratory tract: number of participants isolating other micro‐organisms within the 15‐month · children with cystic fibrosis and a new culture positive for P aeruginosa
1 finding from 1 review