Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,809 questions · 1,956 findings · 194 reviews

No studies found 422 · 21.6%GRADE not reported 427 · 21.8%Very low 353 · 18%Low 397 · 20.3%Moderate 293 · 15%High 64 · 3.3%

Summary of findings: oral vitamin E supplementation vs placebo or no treatment

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Intraoral device releasing Biotene Oral Balance gel vs Manually administered bolus of the same gel

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…

Intraoral device releasing Biotene Oral Balance gel led to lower xerostomia (Xerostomia Inventory) compared with manually administered bolus of the same gel; GRADE not reported.

1 finding from 1 review

Intraoral device releasing Biotene Oral Balance gel vs Manually administered bolus of the same gel

Patient satisfaction · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…

Intraoral device releasing Biotene Oral Balance gel showed no clear difference in patient satisfaction compared with manually administered bolus of the same gel; GRADE not reported.

1 finding from 1 review

Oral glucosamine hydrochloride/chondroitin sulphate vs placebo

Pain on TMJ palpation (ordinal scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral glucosamine hydrochloride/chondroitin sulphate showed no clear difference in pain on TMJ palpation (ordinal scale) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral glucosamine hydrochloride/chondroitin sulphate vs placebo

Total pain rating index (McGill Pain Questionnaire) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral glucosamine hydrochloride/chondroitin sulphate showed no clear difference in total pain rating index (McGill Pain Questionnaire) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral glucosamine hydrochloride/chondroitin sulphate vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral glucosamine hydrochloride/chondroitin sulphate vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral glucosamine hydrochloride/chondroitin sulphate showed no clear difference in pain intensity (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Zinc chloride + sodium chlorite mouthrinse (TriOral) vs Control mouthrinse (containing neither zinc chloride nor sodium chlorite)

Volatile sulphur compounds (VSC), halimeter · Adults over 18 years with a clinical or self-assessed diagnosis of halitosis, without significant comorbidity (e.g. diabetes) or…
1 finding from 1 review
  • Mouthrinses for the treatment of halitosis 2008 · Cochrane All outcomes
    4 weeks
    Codipilly 2004: precise data could not be extracted (results presented as graph plots). Reported VSC reductions from baseline for zinc chloride + sodium chlorite (TriOral): 55% (P < 0.01) at 2 weeks and 60% (P < 0.01)…
    1 study
    GRADE not reported

Zinc chloride + sodium chlorite mouthrinse (TriOral) vs Control mouthrinse (containing neither zinc chloride nor sodium chlorite)

Organoleptic assessment (indirect surrogate salivary organoleptic score) · Adults over 18 years with a clinical or self-assessed diagnosis of halitosis, without significant comorbidity (e.g. diabetes) or…
1 finding from 1 review
  • Mouthrinses for the treatment of halitosis 2008 · Cochrane All outcomes
    4 weeks
    Codipilly 2004: only indirect surrogate salivary organoleptic scores were reported (not organoleptic breath scores); no accurate deductions could be made from the reported values.
    1 study
    GRADE not reported

Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone

Sustained clinically inactive diseasec · children and young people with JIA

Oral methotrexate plus intra‐articular glucocorticoid showed no clear difference in sustained clinically inactive diseaseb(12 months) compared with intra‐articular glucocorticoid alone (low certainty).

1 finding from 1 review

Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone

Withdrawals due to adverse events · children and young people with JIA

Oral methotrexate plus intra‐articular glucocorticoid showed no clear difference in withdrawals due to adverse events(12 months) compared with intra‐articular glucocorticoid alone (low certainty).

1 finding from 1 review

Summary of findings: oral antioxidant combination vs control

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review