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Evidence found and GRADE certainty

1,809 questions · 1,956 findings · 194 reviews

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No studies found 422 · 21.6%GRADE not reported 427 · 21.8%Very low 353 · 18%Low 397 · 20.3%Moderate 293 · 15%High 64 · 3.3%

Summary of findings table ‐ Oral classical immunosuppressants (betamethasone) vs oral classical immunosuppressants (azathioprine, methotrexate, prednisolone)

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

Summary of findings table ‐ Oral classical immunosuppressants… showed no clear difference in short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of compared with oral classical immunosuppressants (azathioprine, methotrexate,… (low certainty).

1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - improvement ('healed' or 'improved' vs 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - improvement ('healed' or 'improved' vs… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review
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Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - healed ('healed' vs 'improved', 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - healed ('healed' vs 'improved',… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review
Show 2 more findings

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Pain · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)
1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Adverse effects · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

The review found no eligible studies for this question.

1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Quality of life · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)
1 finding from 1 review

Oral care interventions (nurse-assisted toothbrushing, oral and pharyngeal cavity rinse, decontamination with antibiotics or antiseptics) vs usual care

Presence of related infection: pneumonia · people with stroke

Oral health care interventions showed no clear difference in presence of related infection: pneumonia (Analysis 1.7) compared with usual care (low certainty).

1 finding from 1 review

Oral care interventions (nurse-assisted toothbrushing, oral and pharyngeal cavity rinse, decontamination with antibiotics or antiseptics) vs usual care

Stroke survivor and providers' knowledge to OHC: knowledge (Analysis 1.8) · people with stroke

It is very uncertain whether oral health care interventions changes stroke survivor and providers' knowledge to OHC: knowledge (Analysis… compared with usual care (very low certainty).

1 finding from 1 review

Oral care interventions (nurse-assisted toothbrushing, oral and pharyngeal cavity rinse, decontamination with antibiotics or antiseptics) vs usual care

Stroke survivor and providers' attitudes to OHC: attitude (Analysis 1.11) · people with stroke

It is very uncertain whether oral health care interventions changes stroke survivor and providers' attitudes to OHC: attitude (Analysis… compared with usual care (very low certainty).

1 finding from 1 review

Chloral hydrate oral (75 mg/kg) vs pentobarbital intravenous (5 mg/kg)

Proportion of children who had sedation failure after 1 dose of sedative agent · children undergoing neurodiagnostic procedures

Chloral hydrate oral (75 mg/kg) may leads to higher proportion of children who had sedation failure after 1 dose of… compared with pentobarbital intravenous (5 mg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (75 mg/kg) vs pentobarbital intravenous (5 mg/kg)

Proportion of children who had sedation failure after 2 doses of sedative agent (same or different) · children undergoing neurodiagnostic procedures

It is very uncertain whether chloral hydrate oral (75 mg/kg) changes proportion of children who had sedation failure after 2 doses of… compared with pentobarbital intravenous (5 mg/kg) (very low certainty).

1 finding from 1 review

Chloral hydrate oral (75 mg/kg) vs pentobarbital intravenous (5 mg/kg)

Non‐interpretable neuroimaging finding · children undergoing neurodiagnostic procedures

It is very uncertain whether chloral hydrate oral (75 mg/kg) changes non‐interpretable neuroimaging finding compared with pentobarbital intravenous (5 mg/kg) (very low certainty).

1 finding from 1 review

Chloral hydrate oral (75 mg/kg) vs pentobarbital intravenous (5 mg/kg)

Number of children with clinical adverse event: oxygen desaturation · children undergoing neurodiagnostic procedures

It is very uncertain whether chloral hydrate oral (75 mg/kg) changes number of children with clinical adverse event: oxygen desaturation compared with pentobarbital intravenous (5 mg/kg) (very low certainty).

1 finding from 1 review