Findings

What do systematic reviews say?

1,809 questions · 1,956 findings · 194 reviews

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No studies found 422 · 21.6%GRADE not reported 427 · 21.8%Very low 353 · 18%Low 397 · 20.3%Moderate 293 · 15%High 64 · 3.3%

Oral antibiotics vs placebo

Subjective improvement in symptoms at 1 month and 3 months · adult participants with chronic blepharitis

1 finding from 1 review

Oral antibiotics for chronic blepharitis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
Very low

Oral antibiotics vs placebo

Measurements of eradication or decrease in numbers of colonies of positive cultures of bacteria · adult participants with chronic blepharitis

The review found no eligible studies for this question.

1 finding from 1 review

Oral antibiotics for chronic blepharitis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral antibiotics vs placebo

Clinical signs—Schirmer test scores at 1 month (mm/5 min) · adult participants with chronic blepharitis

1 finding from 1 review

Oral antibiotics for chronic blepharitis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 93 participants
Very low

Oral antibiotics vs placebo

Clinical signs—TBUT at 1 month (seconds) · adult participants with chronic blepharitis

1 finding from 1 review

Oral antibiotics for chronic blepharitis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 93 participants
Very low

Oral antibiotics vs placebo

Adverse events at 1 month · adult participants with chronic blepharitis

It is very uncertain whether oral antibiotics changes adverse events at 1 month compared with placebo (very low certainty).

1 finding from 1 review

Oral antibiotics for chronic blepharitis 2021 · Cochrane Headline outcomes only
RR 6.13 [1.94, 19.41]
1 study · 93 participants
Very low

Oral antibiotics vs placebo

Quality of life measures · adult participants with chronic blepharitis

The review found no eligible studies for this question.

1 finding from 1 review

Oral antibiotics for chronic blepharitis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral antibiotics vs placebo

Economic costs and benefits of different interventions · adult participants with chronic blepharitis

The review found no eligible studies for this question.

1 finding from 1 review

Oral antibiotics for chronic blepharitis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral misoprostol vs placebo/no treatment

Vaginal birth within 24 hours · women with ruptured membranes in the third trimester for induction of labour.

The review found no eligible studies for this question.

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral misoprostol vs vaginal dinoprostone

Uterine hyperstimulation with fetal heart rate changes · women in the third trimester for induction of labour.

Oral misoprostol may leads to lower uterine hyperstimulation with fetal heart rate changesÂ compared with vaginal dinoprostone (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.49 [0.4, 0.59]
11 studies · 9084 participants
Low

Oral misoprostol vs vaginal dinoprostone

Oxytocin augmentation · women in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes oxytocin augmentationÂ compared with vaginal dinoprostone (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.9 [0.75, 1.09]
12 studies · 9451 participants
Very low

Oral misoprostol vs vaginal dinoprostone

Uterine hyperstimulation without fetal heart rate changes · women in the third trimester for induction of labour.

Oral misoprostol probably leads to lower uterine hyperstimulation without fetal heart rate changesÂ compared with vaginal dinoprostone (moderate certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.83 [0.72, 0.97]
9 studies · 8171 participants
Moderate

Oral misoprostol vs vaginal dinoprostone

Apgar score less than 7 at 5 minutes · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in apgar score less than seven at five minutesÂ compared with vaginal dinoprostone (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.8 [0.52, 1.23]
12 studies · 9473 participants
Low

Oral misoprostol vs vaginal dinoprostone

Admission to neonatal intensive care unit · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in admission to neonatal intensive care unitÂ compared with vaginal dinoprostone (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.8 [0.6, 1.07]
11 studies · 9278 participants
Low

Oral misoprostol vs vaginal misoprostol

Vaginal birth within 24 hours · women in the third trimester for induction of labour.

Oral misoprostol may leads to lower vaginal birth within 24 hoursÂ compared with vaginal misoprostol (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.81 [0.68, 0.95]
16 studies · 3451 participants
Low

Oral misoprostol vs vaginal misoprostol

Caesarean section · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in caesarean section compared with vaginal misoprostol (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1 [0.86, 1.16]
32 studies · 5914 participants
Low

Oral misoprostol vs vaginal misoprostol

Uterine hyperstimulation with fetal heart rate changes · women in the third trimester for induction of labour.

Oral misoprostol may leads to lower uterine hyperstimulation with fetal heart rate changesÂ compared with vaginal misoprostol (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.69 [0.53, 0.92]
25 studies · 4857 participants
Low

Oral misoprostol vs vaginal misoprostol

Oxytocin augmentation · women in the third trimester for induction of labour.

Oral misoprostol may leads to higher oxytocin augmentationÂ compared with vaginal misoprostol (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1.28 [1.15, 1.44]
28 studies · 5416 participants
Low

Oral misoprostol vs vaginal misoprostol

Uterine hyperstimulation without fetal heart rate changes · women in the third trimester for induction of labour.

Oral misoprostol may leads to lower uterine hyperstimulation without fetal heart rate changesÂ compared with vaginal misoprostol (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.69 [0.49, 0.99]
16 studies · 3212 participants
Low

Oral misoprostol vs placebo/no treatment

Caesarean section · women with ruptured membranes in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in caesarean section compared with placebo/no treatment (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.81 [0.59, 1.11]
4 studies · 594 participants
Low

Oral misoprostol vs vaginal misoprostol

Apgar score less than 7 at 5 minutes · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in apgar score less than seven at five minutesÂ compared with vaginal misoprostol (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.68 [0.46, 1.02]
21 studies · 4438 participants
Low