Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,809 questions · 1,956 findings · 194 reviews

No studies found 422 · 21.6%GRADE not reported 427 · 21.8%Very low 353 · 18%Low 397 · 20.3%Moderate 293 · 15%High 64 · 3.3%

Oral cancer patients (cases) vs Healthy controls

Periodontal parameters (all measures pooled) in OC cases vs controls · Adults in case-control studies (oral cancer patients vs healthy controls)

Pooling all periodontal measures, oral cancer patients had worse periodontal status than controls (SMD 0.95, 95% CI 0.41-1.49; very high heterogeneity, I2=96.8%); ungraded. Note this pools clinically different measures.

1 finding from 1 review

Oral cancer patients (cases) vs Healthy controls

Probing pocket depth · Adults in case-control studies (oral cancer patients vs healthy controls)

Periodontal pocket depth did not differ significantly between oral cancer patients and controls (SMD 1.64, 95% CI -0.20 to 3.47; very high heterogeneity); ungraded.

1 finding from 1 review

Oral cancer patients (cases) vs Healthy controls

Alveolar bone loss · Adults in case-control studies (oral cancer patients vs healthy controls)

Alveolar bone loss did not differ significantly between oral cancer patients and controls (SMD 0.18, 95% CI -2.34 to 2.69; extreme heterogeneity); ungraded.

1 finding from 1 review

Oral cancer patients (cases) vs Healthy controls

Dental caries · Adults in case-control studies (oral cancer patients vs healthy controls)

The DMFT index was significantly higher in oral cancer patients than controls (SMD 0.65, 95% CI 0.12-1.18); ungraded.

1 finding from 1 review

Oral cancer patients (cases) vs Healthy controls

Mean number of missing teeth in OC cases vs controls · Adults in case-control studies (oral cancer patients vs healthy controls)

The mean number of missing teeth did not differ significantly between oral cancer patients and controls (SMD 0.59, 95% CI -0.04 to 1.22); ungraded.

1 finding from 1 review

Oral cancer patients (cases) vs Healthy controls

Periodontitis (clinical attachment loss) · Adults in case-control studies (oral cancer patients vs healthy controls)

Clinical attachment loss was significantly greater in oral cancer patients than controls (SMD 1.94, 95% CI 0.22-3.66), though heterogeneity was very high (I2=96.7%); ungraded.

1 finding from 1 review

Systemic (oral) betamethasone vs Topical triamcinolone acetonide paste

Clinical score · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether systemic (oral) betamethasone changes clinical score compared with topical triamcinolone acetonide paste (very low certainty).

1 finding from 1 review

Systemic (oral) betamethasone vs Topical triamcinolone acetonide paste

Pain resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether systemic (oral) betamethasone changes pain resolution compared with topical triamcinolone acetonide paste (very low certainty).

1 finding from 1 review