Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,809 questions · 1,956 findings · 194 reviews

No studies found 422 · 21.6%GRADE not reported 427 · 21.8%Very low 353 · 18%Low 397 · 20.3%Moderate 293 · 15%High 64 · 3.3%

Professional oral care vs Usual oral care

Incidence of NHAP · Residents of nursing homes and other long-term care facilities
1 finding from 1 review
  • Incidence of NHAP, follow-up 8-30 months, 5018 (5 studies), Low. Not pooled (individual and cluster-randomised designs, varying effect measures and follow-up). Component estimates: Bourigault HR 0.65 (0.29 to 1.46;…
    5 studies · 5018 participants
    Low

Professional oral care vs Usual oral care

Mortality (all‐cause) · Residents of nursing homes and other long-term care facilities
1 finding from 1 review
  • All-cause mortality, follow-up 12-30 months, 3764 (3 studies), Very low. Not pooled. Adachi RR 0.80 (0.40 to 1.58; 88); Juthani-Mehta HR 1.16 (0.88 to 1.53; 834); Zimmerman adjusted IRR 0.83 (0.61 to 1.12; 1606).…
    3 studies · 3764 participants
    Very low

Prophylactic aciclovir (oral or intravenous) vs placebo

Presence/absence of HSV oral lesions · Patients being treated for cancer (predominantly haematological malignancies)

Prophylactic aciclovir (oral or intravenous) led to lower presence/absence of HSV oral lesions compared with placebo; GRADE not reported.

1 finding from 1 review

Oral calcium vs vitamin C

Frequency of leg cramps after treatment: never · treating leg cramps in pregnancy

It is very uncertain whether oral calcium changes frequency of leg cramps after treatment: never compared with oral vitamin C (very low certainty).

1 finding from 1 review

Intraoral device releasing Biotene Oral Balance gel vs Manually administered bolus of the same gel

Salivary flow / oral health · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review

Femoral vs subclavian insertion: short‐term catheterization

Immediate mechanical complications ‐ Total mechanical complications · critically ill patients

Femoral showed no clear difference in immediate mechanical complications ‐ Total mechanical complications compared with subclavian insertion: short‐term catheterization (high certainty).

1 finding from 1 review

Femoral vs subclavian insertion: short‐term catheterization

Immediate mechanical complications ‐ Major mechanical complications · critically ill patients

Femoral showed no clear difference in immediate mechanical complications ‐ Major mechanical complications compared with subclavian insertion: short‐term catheterization (high certainty).

1 finding from 1 review

Femoral vs internal jugular insertion: short‐term catheterization

Catheter‐related infectious complications ‐ Catheter colonization · critically ill patients who were expected to require support with renal replacement therapy

Femoral showed no clear difference in catheter‐related infectious complications ‐ Catheter colonization compared with internal jugular insertion: short‐term catheterization (moderate certainty).

1 finding from 1 review

Femoral vs internal jugular insertion: short‐term catheterization

Catheter‐related blood stream infection · critically ill patients who were expected to require support with renal replacement therapy

Femoral showed no clear difference in catheter‐related infectious complications ‐ Catheter related… compared with internal jugular insertion: short‐term catheterization (moderate certainty).

1 finding from 1 review

Femoral vs internal jugular insertion: short‐term catheterization

Catheter‐related infectious complication ‐ Subgroup Analysis for the effect of BMI on catheter colonization ‐ Highest BMI tercile (>28.4) · critically ill patients who were expected to require support with renal replacement therapy

Femoral probably leads to higher catheter‐related infectious complication ‐ Subgroup Analysis for the… compared with internal jugular insertion: short‐term catheterization (moderate certainty).

1 finding from 1 review

Femoral vs internal jugular insertion: short‐term catheterization

Catheter‐related thrombotic complications ‐ Symptomatic deep venous thrombosis · critically ill patients who were expected to require support with renal replacement therapy

Femoral showed no clear difference in catheter‐related thrombotic complications ‐ Symptomatic deep venous… compared with internal jugular insertion: short‐term catheterization (moderate certainty).

1 finding from 1 review

Femoral vs internal jugular insertion: short‐term catheterization

Catheter‐related thrombosis at any time during catheter stay · critically ill patients who were expected to require support with renal replacement therapy

Femoral showed no clear difference in catheter‐related thrombotic complications ‐ Catheter related… compared with internal jugular insertion: short‐term catheterization (moderate certainty).

1 finding from 1 review

Femoral vs internal jugular insertion: short‐term catheterization

Immediate mechanical complications ‐ Total mechanical complications · critically ill patients who were expected to require support with renal replacement therapy

Femoral probably leads to lower immediate mechanical complications ‐ Total mechanical complications compared with internal jugular insertion: short‐term catheterization (moderate certainty).

1 finding from 1 review

Femoral vs internal jugular insertion: short‐term catheterization

Immediate mechanical complications ‐ Major mechanical complications · critically ill patients who were expected to require support with renal replacement therapy

Femoral showed no clear difference in immediate mechanical complications ‐ Major mechanical complications compared with internal jugular insertion: short‐term catheterization (moderate certainty).

1 finding from 1 review

Femoral vs subclavian insertion: short‐term catheterization

Catheter‐related infectious complications ‐ Catheter colonization · critically ill patients

Femoral leads to higher catheter‐related infectious complications ‐ Catheter colonization compared with subclavian insertion: short‐term catheterization (high certainty).

1 finding from 1 review