Findings

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5 questions · 5 findings · 1 reviews · Orthodontics

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No studies found 0 · 0%GRADE not reported 5 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Fluoride-releasing primers/adhesives (Opal Seal; Clearfil Protect Bond) vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control

Enamel demineralization (DIAGNOdent score) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)

Across three small non-randomized studies, fluoride-releasing primers (Opal Seal, Clearfil) showed no consistent clinical advantage over conventional primers in preventing white spot lesions (ungraded).

1 finding from 1 review

Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic… 2024 All outcomes
8 weeks to full treatment (to debonding) · Orthodontic clinical practice (in-vivo human clinical trials); adolescents and adults
Three non-randomized studies (Comert 2020 n=56; Oz 2019 n=35; Oz 2017 n=15) showed no consistent clinical advantage. Comert: no significant difference in photographic WSL severity or area, although DIAGNOdent favored…
3 studies · 106 participants
GRADE not reported

Opal Seal fluoride-releasing primer vs Conventional Transbond XT primer

White spot lesion area · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Opal Seal showed no significant difference in WSL area, with certainty not graded.

1 finding from 1 review

Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic… 2024 All outcomes
During orthodontic treatment · Fixed orthodontic treatment
There was no significant difference in the WSL area between the two groups, with the mean WSL area measuring 161.3 mm2 in the Opal Seal group and 1361.2 mm2 in the conventional group.
1 study · 56 participants
GRADE not reported

Opal Seal fluoride-releasing primer vs Conventional Transbond XT primer

White spot lesions assessed by laser fluorescence (DIAGNOdent) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Opal Seal had fewer DIAGNOdent-measured lesions, with certainty not graded.

1 finding from 1 review

Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic… 2024 All outcomes
During orthodontic treatment · Fixed orthodontic treatment
Opal Seal group showed fewer WSLs compared to the Transbond group, with initial demineralization rates of 1.3% and 3.9%, and caries lesion rates of 0.2% and 1.3%, respectively (p <0.03).
1 study · 56 participants
GRADE not reported

Opal Seal fluoride-releasing primer vs Conventional Transbond XT primer

Photographic white spot lesion score · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Opal Seal showed no difference in photographic WSL severity, with certainty not graded.

1 finding from 1 review

Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic… 2024 All outcomes
During orthodontic treatment · Fixed orthodontic treatment
WSL severity in digital photographs: no significant difference between the two groups (p >0.05).
1 study · 56 participants
GRADE not reported

Opal Seal fluoride-releasing primer vs Conventional Transbond XT primer

Bracket (bond) failure · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Opal Seal showed no difference in bracket failure, with certainty not graded.

1 finding from 1 review

Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic… 2024 All outcomes
During orthodontic treatment · Fixed orthodontic treatment
No significant differences were observed in bracket failure rates among different primers, dental arches, bracket types, or sexes.
1 study · 56 participants
GRADE not reported