Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Gynaecology and Fertility

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 83.3%Moderate 1 · 16.7%High 0 · 0%

Oestrogen tablets vs other regimens

Endometrial thickness (mm) · postmenopausal women with vaginal atrophy

Oestrogen tablets showed no clear difference in endometrial thickness (oestrogen tablets vs oestrogen cream) compared with other regimens (low certainty).

1 finding from 1 review

Local oestrogen for vaginal atrophy in postmenopausal women 2016 · Cochrane Headline outcomes only
OR 0.31 [0.06, 1.6]
2 studies · 151 participants
Low

Oestrogen tablets vs other regimens

Improvement in symptoms (clinician‐assessed) (oestrogen tablets vs oestrogen cream) · postmenopausal women with vaginal atrophy

Oestrogen tablets showed no clear difference in improvement in symptoms (clinician‐assessed) (oestrogen tablets vs… compared with other regimens (low certainty).

1 finding from 1 review

Local oestrogen for vaginal atrophy in postmenopausal women 2016 · Cochrane Headline outcomes only
OR 1.03 [0.7, 1.52]
3 studies · 528 participants
Low

Oestrogen tablets vs other regimens

Improvement in symptoms (clinician‐assessed) (oestrogen tablets vs placebo) · postmenopausal women with vaginal atrophy

Oestrogen tablets may leads to higher improvement in symptoms (clinician‐assessed) (oestrogen tablets vs… compared with other regimens (low certainty).

1 finding from 1 review

Local oestrogen for vaginal atrophy in postmenopausal women 2016 · Cochrane Headline outcomes only
OR 12.85 [10.39, 15.89]
4 studies · 2078 participants
Low

Oestrogen tablets vs other regimens

Adverse events (total adverse events) (oestrogen cream vs non‐hormonal lubricant gel) · postmenopausal women with vaginal atrophy

Oestrogen tablets showed no clear difference in adverse events (total adverse events) (oestrogen tablets vs placebo) compared with other regimens (moderate certainty).

1 finding from 1 review

Local oestrogen for vaginal atrophy in postmenopausal women 2016 · Cochrane Headline outcomes only
OR 1.27 [0.24, 6.69]
1 study · 309 participants
Moderate

Oestrogen tablets vs other regimens

Improvement in symptoms (participant‐assessed) (oestrogen cream vs isoflavone gel) · postmenopausal women with vaginal atrophy

Oestrogen tablets showed no clear difference in improvement in symptoms (participant‐assessed) (oestrogen tablets vs… compared with other regimens (low certainty).

1 finding from 1 review

Local oestrogen for vaginal atrophy in postmenopausal women 2016 · Cochrane Headline outcomes only
OR 1.06 [0.55, 2.01]
2 studies · 208 participants
Low

Oestrogen tablets vs other regimens

Improvement in symptoms (participant‐assessed) (oestrogen tablets vs placebo) · postmenopausal women with vaginal atrophy

Oestrogen tablets may leads to higher improvement in symptoms (participant‐assessed) (oestrogen tablets vs… compared with other regimens (low certainty).

1 finding from 1 review

Local oestrogen for vaginal atrophy in postmenopausal women 2016 · Cochrane Headline outcomes only
OR 12.47 [9.81, 15.84]
2 studies · 1638 participants
Low