Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Headline outcomes only

Sort:Best matchNewest Highest certainty Download CSV

No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 5 · 71.4%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

NSAIDs vs placebo

Participant‐reported pain relief of 50% or greater · adults with sickle cell disease in a vaso‐occlusive crisis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

Participant‐reported pain relief of 30% or greater · adults with sickle cell disease in a vaso‐occlusive crisis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

PGIC very much improved · adults with sickle cell disease in a vaso‐occlusive crisis

It is very uncertain whether non‐steroidal anti‐inflammatory drugs (NSAID) changes PGIC very much improved ( compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
RR 7.64 [0.44, 131.75]
1 study · 21 participants
Very low

NSAIDs vs placebo

Patient Global Impression of Change much or very much improved · adults with sickle cell disease in a vaso‐occlusive crisis

It is very uncertain whether non‐steroidal anti‐inflammatory drugs (NSAID) changes PGIC much or very much improved ( compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
RR 1.65 [0.65, 4.19]
1 study · 21 participants
Very low

NSAIDs vs placebo

Any adverse event ( · adults with sickle cell disease in a vaso‐occlusive crisis

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 72 participants
Very low

NSAIDs vs placebo

Serious adverse events ( · adults with sickle cell disease in a vaso‐occlusive crisis

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 93 participants
Very low

NSAIDs vs placebo

Withdrawals due to adverse events · adults with sickle cell disease in a vaso‐occlusive crisis

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 93 participants
Very low