Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 1 · 20%Very low 0 · 0%Low 3 · 60%Moderate 1 · 20%High 0 · 0%

Vaginal delivery not achieved within 24 hours · pregnant women undergoing cervical ripening and induction of labour

Nitric oxide donors showed no clear difference in vaginal delivery not achieved in 24 hours compared with placebo (low certainty).

1 finding from 1 review

Nitric oxide donors for cervical ripening and induction of labour 2016 · Cochrane Headline outcomes only
RR 0.97 [0.83, 1.15]
1 study · 238 participants
Low

Uterine hyperstimulation with fetal heart rate changes · pregnant women undergoing cervical ripening and induction of labour

Nitric oxide donors showed no clear difference in uterine hyperstimulation with FHR changes compared with placebo (low certainty).

1 finding from 1 review

Nitric oxide donors for cervical ripening and induction of labour 2016 · Cochrane Headline outcomes only
RR 0.09 [0.01, 1.62]
2 studies · 300 participants
Low

Caesarean section · pregnant women undergoing cervical ripening and induction of labour

Nitric oxide donors showed no clear difference in caesarean section compared with placebo (moderate certainty).

1 finding from 1 review

Nitric oxide donors for cervical ripening and induction of labour 2016 · Cochrane Headline outcomes only
RR 0.99 [0.88, 1.11]
9 studies · 2624 participants
Moderate

Serious neonatal morbidity or perinatal death · pregnant women undergoing cervical ripening and induction of labour

Nitric oxide donors showed no clear difference in serious neonatal morbidity/perinatal death compared with placebo (low certainty).

1 finding from 1 review

Nitric oxide donors for cervical ripening and induction of labour 2016 · Cochrane Headline outcomes only
RR 1.61 [0.08, 33.26]
2 studies · 1712 participants
Low

Serious maternal morbidity or death · pregnant women undergoing cervical ripening and induction of labour

1 finding from 1 review

Nitric oxide donors for cervical ripening and induction of labour 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1362 participants
GRADE not reported