Cochrane · systematic review · CD006901
Nitric oxide donors for cervical ripening and induction of labour
Ghosh, A, Lattey, KR, Kelly, AJ · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 20%Very low 0 · 0%Low 3 · 60%Moderate 1 · 20%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Nitric oxide donors versus placebo for cervical ripening and induction of labour
Population: pregnant women undergoing cervical ripening and induction of labour
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Vaginal delivery not achieved in 24 hours Nitric oxide donors vs placebo | RR 0.97 [0.83, 1.15] | 1 study · 238 participants | Low Downgraded: imprecision |
Uterine hyperstimulation with FHR changes Nitric oxide donors vs placebo | RR 0.09 [0.01, 1.62] | 2 studies · 300 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Caesarean section Nitric oxide donors vs placebo | RR 0.99 [0.88, 1.11] | 9 studies · 2624 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Serious neonatal morbidity/perinatal death Nitric oxide donors vs placebo | RR 1.61 [0.08, 33.26] | 2 studies · 1712 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Serious maternal morbidity or death Nitric oxide donors vs placebo | no estimate extracted | 1 study · 1362 participants | Ungraded |