Findings

What do systematic reviews say?

15 questions · 15 findings · 2 reviews · Pain, Palliative and Supportive Care

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No studies found 2 · 13.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 6.7%Moderate 7 · 46.7%High 5 · 33.3%

Naproxen 500 mg or 825 mg vs placebo

Pain‐free at 2 hours · migraine headache ‐ moderate or severe pain

1 finding from 1 review

Naproxen with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Naproxen 500 mg or 825 mg vs placebo

Headache relief at 2 h · migraine headache ‐ moderate or severe pain

1 finding from 1 review

Naproxen with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Naproxen 500 mg or 825 mg vs placebo

Sustained pain‐free at 24 h · migraine headache ‐ moderate or severe pain

1 finding from 1 review

Naproxen with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Naproxen 500 mg or 825 mg vs placebo

Sustained headache relief at 24 h · migraine headache ‐ moderate or severe pain

1 finding from 1 review

Naproxen with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Naproxen 500 mg or 825 mg vs placebo

Number of participants reporting an adverse event · migraine headache ‐ moderate or severe pain

1 finding from 1 review

Naproxen with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Naproxen 500 mg or 825 mg vs placebo

Serious AE · migraine headache ‐ moderate or severe pain

The review found no eligible studies for this question.

1 finding from 1 review

Naproxen with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo

Pain‐free response at 2 h for moderate to severe baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

1 finding from 1 review

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo

Pain‐free response at 2 h for mild baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

1 finding from 1 review

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo

Headache relief at 2 h for moderate to severe baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

1 finding from 1 review

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo

Sustained pain‐free during the 24 h post dose for moderate to severe baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

1 finding from 1 review

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo

Sustained pain‐free during the 24 h post dose for mild baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

1 finding from 1 review

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo

Sustained headache relief during the 24 h post dose for moderate or severe baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

1 finding from 1 review

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo

At least 1 AE during treatment for moderate to severe baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

1 finding from 1 review

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo

At least 1 AE during treatment for mild baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

1 finding from 1 review

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo

Serious AE (all levels of baseline pain) · adults with migraine headache ‐ moderate or severe and mild baseline pain

The review found no eligible studies for this question.

1 finding from 1 review

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found