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What do systematic reviews say?

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Evidence found and GRADE certainty

33 questions · 35 findings · 2 reviews · Pregnancy and Childbirth

No studies found 14 · 40%GRADE not reported 2 · 5.7%Very low 8 · 22.9%Low 8 · 22.9%Moderate 3 · 8.6%High 0 · 0%

NSAIDs vs placebo

Adequate pain relief as reported by women · women with perineal pain in the early postpartum period

NSAID may leads to higher adequate pain relief(4 hours after administration) compared with placebo (low certainty).

2 findings from 1 review

NSAIDs vs placebo

Need for additional analgesia (6 hours after administration) · women with perineal pain in the early postpartum period

It is very uncertain whether NSAID changes need for additional analgesia (6 hours after administration) compared with placebo (very low certainty).

1 finding from 1 review

NSAIDs vs placebo

Relief of pain · women who have given birth vaginally, requiring analgesia for after‐birth pains.

NSAID probably leads to higher adequate pain relief as reported by the woman (5 to 8 hours) compared with placebo (moderate certainty).

1 finding from 1 review

NSAIDs vs opioid

Maternal adverse events (6 to 8 hours) · women who have given birth vaginally, requiring analgesia for after‐birth pains.

NSAID may leads to lower maternal adverse events (6 to 8 hours) compared with opioid (low certainty).

1 finding from 1 review

NSAIDs vs placebo

Additional pain relief · women who have given birth vaginally, requiring analgesia for after‐birth pains.

NSAID may leads to lower need for additional pain relief (5 to 8 hours) compared with placebo (low certainty).

1 finding from 1 review

NSAIDs vs placebo

Maternal adverse events · women who have given birth vaginally, requiring analgesia for after‐birth pains.

NSAID showed no clear difference in maternal adverse events (4 to 8 hours) compared with placebo (low certainty).

1 finding from 1 review

NSAIDs vs herbal analgesia

Relief of pain · women who have given birth vaginally, requiring analgesia for after‐birth pains.

It is very uncertain whether NSAID changes adequate pain relief as reported by the woman (1 to 4 hours) compared with herbal analgesia (very low certainty).

1 finding from 1 review

NSAIDs vs herbal analgesia

Need for additional analgesia (4 hours after administration) · women who have given birth vaginally, requiring analgesia for after‐birth pains.

It is very uncertain whether NSAID changes need for additional pain relief (4 hours) compared with herbal analgesia (very low certainty).

1 finding from 1 review

NSAIDs vs herbal analgesia

Maternal adverse events · women who have given birth vaginally, requiring analgesia for after‐birth pains.

It is very uncertain whether NSAID changes maternal adverse events (1 hour) compared with herbal analgesia (very low certainty).

1 finding from 1 review