What do systematic reviews say?

Any antibiotic regimen plus N‐acetylcysteine vs the same regimen without N‐acetylcysteine (with or without placebo)

It is very uncertain whether any antibiotic regimen plus N‐acetylcysteine changes eradication rate compared with the same regimen without N‐acetylcysteine (with or without placebo) (very low certainty).

• N‐acetylcysteine as an adjuvant therapy for Helicobacter pylori eradication 2019 · Cochrane Headline outcomes only
  RR 0.74 [0.51, 1.08]
  8 studies · 559 participants
  Very low

Any antibiotic regimen plus N‐acetylcysteine vs the same regimen without N‐acetylcysteine (with or without placebo)

It is very uncertain whether any antibiotic regimen plus N‐acetylcysteine changes gastrointestinal adverse events compared with the same regimen without N‐acetylcysteine (with or without placebo) (very low certainty).

• N‐acetylcysteine as an adjuvant therapy for Helicobacter pylori eradication 2019 · Cochrane Headline outcomes only
  RR 1.25 [0.85, 1.85]
  5 studies · 336 participants
  Very low

Any antibiotic regimen plus N‐acetylcysteine vs the same regimen without N‐acetylcysteine (with or without placebo)

It is very uncertain whether any antibiotic regimen plus N‐acetylcysteine changes allergic adverse events compared with the same regimen without N‐acetylcysteine (with or without placebo) (very low certainty).

• N‐acetylcysteine as an adjuvant therapy for Helicobacter pylori eradication 2019 · Cochrane Headline outcomes only
  RR 2.98 [0.32, 27.74]
  5 studies · 336 participants
  Very low

Any antibiotic regimen plus N‐acetylcysteine vs the same regimen without N‐acetylcysteine (with or without placebo)

• N‐acetylcysteine as an adjuvant therapy for Helicobacter pylori eradication 2019 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 336 participants
  Low